Protein Info for IAI46_17310 in Serratia liquefaciens MT49

Annotation: cyclic di-GMP phosphodiesterase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 528 transmembrane" amino acids 21 to 40 (20 residues), see Phobius details amino acids 243 to 265 (23 residues), see Phobius details PF12792: CSS-motif" amino acids 53 to 230 (178 residues), 72 bits, see alignment E=5.1e-24 PF00563: EAL" amino acids 271 to 505 (235 residues), 222.5 bits, see alignment E=5.3e-70

Best Hits

Swiss-Prot: 48% identical to PDEN_ECOLI: Probable cyclic di-GMP phosphodiesterase PdeN (pdeN) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 91% identity to spe:Spro_3245)

Predicted SEED Role

"Rtn protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (528 amino acids)

>IAI46_17310 cyclic di-GMP phosphodiesterase (Serratia liquefaciens MT49)
MGLKRAFARHVSHRRRSLAKSAIVALVFFILFMAITLSLIDHQRTQYQHRVEQRTQKFTA
DTLHDLTTIMQQLMPLIDRPCSASQPDITYQAAFHSGVRTFMLVKNGFAYCSSATGEMML
ALKNIYPEIDPHQSLDLKLQQGTPLVPGKPAVAVWLRQPGKEDTGVLATLDIALMPYQLF
TSRPERAPAIAIILGDRALTSFSPNLMPVNQLPNEKADRISIAGTPMTILFYNQKLTPND
IRLTLMGSLVLSLMIGVLCYYMLLLRQSPERALMRGIKRNEFFIEYQPVFHTQSGTIGGL
EALIRWQHPIEGRIPPDLFIPYAESEGLIVPLTRHLFRLIAEDAPKLATALPQGAKLGLN
ISPSHLSAPSFHHDVYELLAQLPGDYFTLVFEITERGMVEEGNALAEFDWLHQQGIEIAI
DDFGTGHSALIYLERFSMDYLKIDRGFVNSIGQDTVTAPVLDAVISLAKKLKMQTVAEGV
ETAEQVSFLQEQDVNFMQGYYYSRPLSIDNFVAFCNAHTVMDHQALKG