Protein Info for IAI46_17305 in Serratia liquefaciens MT49

Annotation: bifunctional murein DD-endopeptidase/murein LD-carboxypeptidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00877: NLPC_P60
  • amino acids 82 to 186 (105 residues), 120.5 bits, E=1.5e-39

Best Hits

Swiss-Prot: 72% identical to MEPS_SHIFL: Murein DD-endopeptidase MepS/Murein LD-carboxypeptidase (mepS) from Shigella flexneri

KEGG orthology group: K13694, lipoprotein Spr (inferred from 100% identity to spe:Spro_3244)

MetaCyc: 72% identical to peptidoglycan endopeptidase/peptidoglycan L,D-carboxypeptidase (Escherichia coli K-12 substr. MG1655)
Muramoyltetrapeptide carboxypeptidase. [EC: 3.4.17.13]; 3.4.-.- [EC: 3.4.17.13]; 3.4.-.- [EC: 3.4.17.13]

Predicted SEED Role

"Lipoprotein spr precursor"

MetaCyc Pathways

• peptidoglycan recycling I (13/14 steps found)
• muropeptide degradation (3/4 steps found)
• peptidoglycan recycling II (6/10 steps found)
• peptidoglycan maturation (meso-diaminopimelate containing) (4/12 steps found)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.17.13

Protein Sequence (191 amino acids)

>IAI46_17305 bifunctional murein DD-endopeptidase/murein LD-carboxypeptidase (Serratia liquefaciens MT49)
MVKSQPFLRYFLRVVPAIAAAVMLSACSTTHTSNLNNAQTEMRAVNDKDGLLLQASQDEF
EAMVRNVDVKSKIMDQYADWKGVRYRLGGETKRGIDCSAFVQRTFREQFGMDLPRSTYEQ
EDMGKKILRTKLRPGDLVLFRAGSTGRHVGIYLGNDQFVHASTSNGVMISKLSDNYWNKR
YREARRVLTSS