Protein Info for IAI46_17300 in Serratia liquefaciens MT49

Annotation: phosphatase PAP2 family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 234 transmembrane" amino acids 7 to 25 (19 residues), see Phobius details amino acids 63 to 80 (18 residues), see Phobius details amino acids 92 to 113 (22 residues), see Phobius details amino acids 147 to 165 (19 residues), see Phobius details amino acids 171 to 192 (22 residues), see Phobius details amino acids 198 to 220 (23 residues), see Phobius details PF01569: PAP2" amino acids 96 to 206 (111 residues), 39.2 bits, see alignment E=2.9e-14

Best Hits

Swiss-Prot: 62% identical to LPXT_ECOLI: Lipid A 1-diphosphate synthase (lpxT) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 93% identity to spe:Spro_3242)

MetaCyc: 62% identical to lipid A-core phosphotransferase (Escherichia coli K-12 substr. MG1655)
Undecaprenyl-diphosphatase. [EC: 3.6.1.27]; RXN-16281 [EC: 3.6.1.27, 2.7.4.29]; 2.7.4.29 [EC: 3.6.1.27, 2.7.4.29]

Predicted SEED Role

"Putative membrane protein"

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.6.1.27

Use Curated BLAST to search for 2.7.4.29 or 3.6.1.27

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (234 amino acids)

>IAI46_17300 phosphatase PAP2 family protein (Serratia liquefaciens MT49)
MTRRNLPLIIFFNILGIVLFLSWFLPANHGYWFTLDSEIFFFFNRHLATDPGFLHLVAIT
NNRAFDVISLLAMGLLYLCFYLQQDGAGRRRLLITGVVMLLTAVVLNQLGHLLPVKHPSP
SLSFENINRVSELTGIPTKDASGDSFPGDHGMMLMIFSCFMLRYFNRRAFAVALLITVVF
SLPRVMIGAHWFTDIAVGSLSVVLVGASWCLMTPFSDVLIRGLNRLLPGKHRPA