Protein Info for IAI46_16185 in Serratia liquefaciens MT49

Annotation: metalloregulator ArsR/SmtB family transcription factor

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 109 PF12840: HTH_20" amino acids 13 to 60 (48 residues), 30 bits, see alignment E=3.9e-11 PF01022: HTH_5" amino acids 16 to 60 (45 residues), 55.5 bits, see alignment E=4.3e-19

Best Hits

Swiss-Prot: 66% identical to ARSR1_ECOLX: Arsenical resistance operon repressor (arsR) from Escherichia coli

KEGG orthology group: None (inferred from 79% identity to srs:SerAS12_3111)

MetaCyc: 57% identical to DNA-binding transcriptional repressor ArsR (Escherichia coli K-12 substr. MG1655)

Predicted SEED Role

"Arsenical resistance operon repressor" in subsystem Arsenic resistance

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (109 amino acids)

>IAI46_16185 metalloregulator ArsR/SmtB family transcription factor (Serratia liquefaciens MT49)
MTSLTPLALFKNLSEETRLTLVLLLRQAGELCVCELVSALEESQPKVSRHLAMLRESGLL
IDRREGKWIYYRLSPHMPAWAAAIIEQAYLSRQQQVTELAQRALGAVCR