Protein Info for IAI46_16120 in Serratia liquefaciens MT49

Annotation: aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00155: Aminotran_1_2
  • amino acids 205 to 400 (196 residues), 46.1 bits, E=2.1e-16

Best Hits

KEGG orthology group: None (inferred from 91% identity to spe:Spro_3028)

Predicted SEED Role

"2-amino-3-ketobutyrate coenzyme A ligase (EC 2.3.1.29)" in subsystem Glycine Biosynthesis or Glycine and Serine Utilization (EC 2.3.1.29)

MetaCyc Pathways

• superpathway of L-threonine metabolism (15/18 steps found)
• L-threonine degradation II (2/2 steps found)

KEGG Metabolic Maps

• Glycine, serine and threonine metabolism

Isozymes

Compare fitness of predicted isozymes for: 2.3.1.29

Use Curated BLAST to search for 2.3.1.29

Protein Sequence (407 amino acids)

>IAI46_16120 aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme (Serratia liquefaciens MT49)
MSSRKQIIPTNKFRNNDKAIGIGNPFWDMSEQNGLAGIVAGLDNDLLSTQSGHQFVNFSC
CSYLNLDSHSKVVEGAIDAVRRYGVLDHCIARSRVQLPAMKELEASLGELFQADVLSGVS
ASSVSGGLLPLIASGHLGNGVRPLMIFDKHAHVSLAAAKPACADETEVVTCNYHDLNFIE
DCCKQYQRVCYVVDGSDSLGGYAPVKALAELQDKYGLMVFYDDSHSISAYGERGVGYVRS
HSPALDENTIMVVTLNKAFGTSGAAILLNGYSQQMLRLVERFGGGLNYSQNLNTAAIGAS
LASAEIHRTAELPRLQKKLYDNIALFDSLIPTEQSGNTYPIRLVPMSDDRVIEAGRQVIE
AGFYVSPVFFPIVAKGTAGLRVMMRAGQTQEQIRGLCQVISAVRGPQ