Protein Info for IAI46_15690 in Serratia liquefaciens MT49

Annotation: sodium-potassium/proton antiporter ChaA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 366 transmembrane" amino acids 16 to 33 (18 residues), see Phobius details amino acids 39 to 60 (22 residues), see Phobius details amino acids 74 to 96 (23 residues), see Phobius details amino acids 108 to 129 (22 residues), see Phobius details amino acids 145 to 163 (19 residues), see Phobius details amino acids 170 to 190 (21 residues), see Phobius details amino acids 221 to 240 (20 residues), see Phobius details amino acids 258 to 279 (22 residues), see Phobius details amino acids 289 to 311 (23 residues), see Phobius details amino acids 317 to 338 (22 residues), see Phobius details amino acids 347 to 365 (19 residues), see Phobius details TIGR00846: calcium/proton exchanger" amino acids 11 to 365 (355 residues), 346.1 bits, see alignment E=1.1e-107 PF01699: Na_Ca_ex" amino acids 42 to 192 (151 residues), 54.4 bits, see alignment E=7.4e-19 amino acids 223 to 365 (143 residues), 36.1 bits, see alignment E=3.1e-13

Best Hits

Swiss-Prot: 80% identical to CHAA_ECOLI: Sodium-potassium/proton antiporter ChaA (chaA) from Escherichia coli (strain K12)

KEGG orthology group: K07300, Ca2+:H+ antiporter (inferred from 98% identity to srs:SerAS12_3004)

MetaCyc: 80% identical to Na+/K+:H+ antiporter ChaA (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-101; TRANS-RXN-42

Predicted SEED Role

"Calcium/proton antiporter"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (366 amino acids)

>IAI46_15690 sodium-potassium/proton antiporter ChaA (Serratia liquefaciens MT49)
MKSQNDPGRSKSRHTEYSLLFPIAALVVLNLWGSTSNFPLIVGINIIALVGILSSAFSVV
RHADVLAHRLGEPYGSLILSLSVVILEVSLISALMATGDAAPALMRDTLYSIIMIVSAGL
VGFALLLGGRKFATQYVNLGGIKQYLMAIFPLAVIVLVFPSALPGGNFSTGQALLVAVIS
AAMYGVFLVIQTKTHQSLFVYEHEDDDGDPHHGKPSSHSSAWHAGWLVVHLIAVIAVTKF
NANPLEGLLTKVNAPAQFTGFLVALLILSPEGLGALRAVLNNQVQRAMNLFFGSVLATIS
LTVPAVTIIATLTGQTLIFGLQTPHIVVMLTVLLLCQLSFSTGRTNVLNGTAHLALFAAY
MMTIFA