Protein Info for IAI46_15575 in Serratia liquefaciens MT49

Annotation: polysaccharide biosynthesis tyrosine autokinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 726 transmembrane" amino acids 32 to 56 (25 residues), see Phobius details amino acids 429 to 453 (25 residues), see Phobius details PF02706: Wzz" amino acids 21 to 111 (91 residues), 50.5 bits, see alignment E=6.2e-17 PF13807: GNVR" amino acids 371 to 452 (82 residues), 109.5 bits, see alignment E=1.9e-35 TIGR01007: capsular exopolysaccharide family" amino acids 513 to 715 (203 residues), 161.6 bits, see alignment E=9e-52 PF10609: ParA" amino acids 532 to 701 (170 residues), 27.3 bits, see alignment E=7e-10 PF09140: MipZ" amino acids 541 to 650 (110 residues), 31.3 bits, see alignment E=4.1e-11 PF01656: CbiA" amino acids 542 to 703 (162 residues), 30.1 bits, see alignment E=1.2e-10 PF13614: AAA_31" amino acids 543 to 658 (116 residues), 42.1 bits, see alignment E=2.9e-14

Best Hits

KEGG orthology group: K00903, protein-tyrosine kinase [EC: 2.7.10.-] (inferred from 96% identity to spe:Spro_2893)

Predicted SEED Role

"Tyrosine-protein kinase Wzc (EC 2.7.10.2)" in subsystem Colanic acid biosynthesis (EC 2.7.10.2)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.10.2

Use Curated BLAST to search for 2.7.10.- or 2.7.10.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (726 amino acids)

>IAI46_15575 polysaccharide biosynthesis tyrosine autokinase (Serratia liquefaciens MT49)
MMKNNALPIVMAEQDDKLEWERLIGPLWDNRWRILLVTGVAGILGCAYALMATPIYQATA
LVQVEKQLSGDSLLRETLDSSIGGVGQNSATQDEVSLAKSRYVIGKTVDDLGLTVRISPD
YFPLFGKGIARLSGEVTPVLRFSSMKVPAVMQGQELTLTVDDPQHYSLSHDGKTLFSGVV
GQTLQQGGWSVNVSELEAQPGTTFTVVNVPRQKAVDDLRNILDVAPGGKESGIMTFSLAG
EDPQRAEAVLKSITDNYLQQNVDRKTEEAQRMLAFLHEQLPRTQTSLNNAENQLNQFRQQ
NDSVDLSLEAKSVLDTQVQLEGQLNELTFKEAEISKLYTRVHPAYRALLEKRATLEAEKA
RLGKQVQTLPKTQQEILRLTRDVQVDQQVYMQLMNKQQELSISKAGTVGNIRIIDEAETG
LRPVQPQKAMIVFFALLMGGVLSASVVVLRAALHRGISDTDTLEKRGISVYATVPLSPWQ
QKRNRVQQQLLTKHSSGKLPILAQEEPEDLSVEAIRSLRTSLHFAMMEAKNNILMVSGAS
PASGKSFTSTNLAVVIAQAGQRVLLIDADMRKGFLHRWLNNSAKAGLSDMLSGLIAPEMA
VKKTDIANLDFVPRGQVPPNPSELLMHQRFADFLRWAGQNYDLVLIDTPPVLAVTDAAIV
GHHAGTALMVVRFEVNTVRQIETSIRRFEQNGVAIKGVILNGMVKKTATDAGYYAFAYPS
HQEKVQ