Protein Info for IAI46_15335 in Serratia liquefaciens MT49

Annotation: aspartate aminotransferase family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR03246: succinylornithine transaminase family
  • amino acids 7 to 403 (397 residues), 734.6 bits, E=2.7e-225
• TIGR00707: transaminase, acetylornithine/succinylornithine family
  • amino acids 15 to 399 (385 residues), 515.8 bits, E=6.2e-159
• PF00202: Aminotran_3
  • amino acids 25 to 399 (375 residues), 424.3 bits, E=4.2e-131
• PF00155: Aminotran_1_2
  • amino acids 173 to 368 (196 residues), 22.7 bits, E=5.3e-09

Best Hits

Swiss-Prot: 76% identical to ASTC_YERE8: Succinylornithine transaminase (astC) from Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)

KEGG orthology group: K00840, succinylornithine aminotransferase [EC: 2.6.1.81] (inferred from 96% identity to spe:Spro_2844)

MetaCyc: 71% identical to succinylornithine transaminase (Escherichia coli K-12 substr. MG1655)
Succinylornithine transaminase. [EC: 2.6.1.81]; Acetylornithine transaminase. [EC: 2.6.1.81, 2.6.1.11]

Predicted SEED Role

"Succinylornithine transaminase (EC 2.6.1.81)" in subsystem Arginine and Ornithine Degradation (EC 2.6.1.81)

MetaCyc Pathways

• superpathway of arginine and polyamine biosynthesis (17/17 steps found)
• L-arginine biosynthesis I (via L-ornithine) (9/9 steps found)
• L-arginine biosynthesis II (acetyl cycle) (9/10 steps found)
• L-arginine biosynthesis III (via N-acetyl-L-citrulline) (8/9 steps found)
• L-arginine degradation II (AST pathway) (5/5 steps found)
• L-ornithine biosynthesis I (5/5 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism
• Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
• Lysine biosynthesis
• Urea cycle and metabolism of amino groups

Isozymes

Compare fitness of predicted isozymes for: 2.6.1.11, 2.6.1.81

Use Curated BLAST to search for 2.6.1.11 or 2.6.1.81

Protein Sequence (404 amino acids)

>IAI46_15335 aspartate aminotransferase family protein (Serratia liquefaciens MT49)
MEQPIAVTRQSFDDWMVPVYAPADFILVRGEGSQVWDQQGKSYIDFAGGIAVNALGHAHP
VVTAALVEQAGKLWHLGNGYTNEPVLRLAKLLIDATFAEKVFFCNSGAEANEAALKLARK
RALDNGNHSKNQIVAFNNAFHGRTLFTVSAGGQPKYSKDFAPLPGGITHTPFNDLAAAAE
VINDNTCAVIVEPIQGEGGVLPADAAFLQGLRELCDRHDALLIFDEVQTGMGRTGDLYAY
MQYGVVPDVLTTAKALGCGFPIGAMLTTDELAKTLSVGTHGTTYGGNPLATAVAGAVFSV
INTPEVLEGVKQRHQWFLDGLNKINQQYPIFSEIRGGGLLIGCQLTKDYAGKAKQITQLA
NEEGVIALIAGPDVVRFTPSLVIPEQDVKEGLARFARAVARICS