Protein Info for IAI46_15325 in Serratia liquefaciens MT49

Annotation: succinylglutamate-semialdehyde dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 490 TIGR03240: succinylglutamate-semialdehyde dehydrogenase" amino acids 6 to 489 (484 residues), 857.3 bits, see alignment E=1.6e-262 PF00171: Aldedh" amino acids 12 to 463 (452 residues), 398.8 bits, see alignment E=1.4e-123

Best Hits

Swiss-Prot: 96% identical to ASTD_SERP5: N-succinylglutamate 5-semialdehyde dehydrogenase (astD) from Serratia proteamaculans (strain 568)

KEGG orthology group: K06447, succinylglutamic semialdehyde dehydrogenase [EC: 1.2.1.71] (inferred from 96% identity to spe:Spro_2842)

MetaCyc: 68% identical to aldehyde dehydrogenase (Escherichia coli K-12 substr. MG1655)
Succinylglutamate-semialdehyde dehydrogenase. [EC: 1.2.1.71]

Predicted SEED Role

"Succinylglutamic semialdehyde dehydrogenase (EC 1.2.1.71)" in subsystem Arginine and Ornithine Degradation (EC 1.2.1.71)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.2.1.71

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (490 amino acids)

>IAI46_15325 succinylglutamate-semialdehyde dehydrogenase (Serratia liquefaciens MT49)
MSHPALFINGAWQQGHGAAFSKTDPVDNQPLWQANAADGSDVAAACEAARAAFPAWARTP
FEQREQLVKRFAALLEEHKSSLAAVISRETSKPRWETLTEVQAMIGKVAISLQAYQARTG
VSQTAMADGASVLRHRPHGVLAVFGPYNFPGHLPNGHIVPALLAGNTVVFKPSELTPQTA
EETLKLWQQAGLPDGVLNLVQGGRETGEALAASADIDGLLFTGSAGTGYHLHRQLAGQPE
KILALEMGGNNALIIDQIEDRDATVNLAIQSAFISAGQRCTCSRRILVKRGSEGDAFIER
LVQVASALRVGRWDAEPQPFMGGVISSAAAEKMLAAQHHLLALGGNALLTMQRLESGSAL
LSPGIIDVTGVRDVPDEEYFGPLTTIIRYNDFDEALRIANQTRYGLSVGLVSSQREQFDH
LLLEARAGIVNWNKPLTGASSAAPFGGVGASGNHRPSAYYAADYCAWPMASLESESLTLP
ASLSPGLSFN