Protein Info for IAI46_14160 in Serratia liquefaciens MT49

Annotation: glycerol kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00370: FGGY_N
  • amino acids 6 to 235 (230 residues), 186 bits, E=9.7e-59
• PF02782: FGGY_C
  • amino acids 249 to 434 (186 residues), 87.6 bits, E=1e-28

Best Hits

Swiss-Prot: 35% identical to GLPK_HALWD: Glycerol kinase (glpK) from Haloquadratum walsbyi (strain DSM 16790 / HBSQ001)

KEGG orthology group: K00864, glycerol kinase [EC: 2.7.1.30] (inferred from 96% identity to spe:Spro_2692)

Predicted SEED Role

"Carbohydrate kinase, FGGY"

MetaCyc Pathways

• glycerol and glycerophosphodiester degradation (4/4 steps found)
• glycerol degradation I (3/3 steps found)

KEGG Metabolic Maps

• Glycerolipid metabolism

Isozymes

Compare fitness of predicted isozymes for: 2.7.1.30

Use Curated BLAST to search for 2.7.1.30

Protein Sequence (480 amino acids)

>IAI46_14160 glycerol kinase (Serratia liquefaciens MT49)
MLNQRYAAIDQGTTGTRVVVFGEDGKHFSPAAIAHKQLTPNPGWVEHDPMEILRNIRTCL
SQCGVVDAIGLAHQGESVVAWDAQSGLPLYNAIIWQDQRTESVIRQLRNEGFEETIRAKT
GLPLDTYFSGSKLGWIMRNVPGARELSRRGHLRLGTMDSFFMFHLCGTHITDYNSASRTS
LFNIHTLQWDEELCRLFGVPIEALPNIRDNTGHFGDVTYAGNTTPLTACIVDQFAGTYGH
GCLQPGQMKITFGTGAFLQSITGTKVPDAQGSGLLPTLCWKLPGEPPLYGLDGGVYNAAS
AINWAKKIGLYSDIEEFSDFPDEPAIARGLAFIPALSGLGCPYWDRSAAGLWAGLSLETE
RKDMLQSILEGIAMRSAEVIYAMDKVRPIGDTISVDGGLSANLYFKQFLASLIQKRIVTP
ANREITAQGVALLARKGLGNTHPMNVRTQHVTTEPAERDLSPYFAKYKDIISRSRNLRGE