Protein Info for IAI46_14105 in Serratia liquefaciens MT49

Annotation: TonB system transport protein TonB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 248 signal peptide" amino acids 1 to 33 (33 residues), see Phobius details PF16031: TonB_N" amino acids 37 to 167 (131 residues), 72.4 bits, see alignment E=6e-24 PF03544: TonB_C" amino acids 171 to 241 (71 residues), 66.5 bits, see alignment E=2.4e-22 TIGR01352: TonB family C-terminal domain" amino acids 171 to 241 (71 residues), 67.8 bits, see alignment E=4e-23

Best Hits

Swiss-Prot: 90% identical to TONB_SERMA: Protein TonB (tonB) from Serratia marcescens

KEGG orthology group: K03832, periplasmic protein TonB (inferred from 94% identity to spe:Spro_2682)

MetaCyc: 54% identical to Ton complex subunit TonB (Escherichia coli K-12 substr. MG1655)

Predicted SEED Role

"Ferric siderophore transport system, periplasmic binding protein TonB" in subsystem Campylobacter Iron Metabolism or Hemin transport system or Ton and Tol transport systems

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (248 amino acids)

>IAI46_14105 TonB system transport protein TonB (Serratia liquefaciens MT49)
MPLKKMFLNRRLSVPIVLSVGLHSALVAGLLYASVKEVMELPKPEDAPISVMMVNTAAMA
EPPPPAPAEPEPEPQVEPEPEPEPEPIPEPPPKAILKPEPVKPKPKPKPKPKVEKTVKRE
PQKTEPREPSPFENNQPAKPIDKAPVKQAPSAPVAGNSRDVAPRALSRVDPIYPPRARAL
QIEGNVRVQFDIDSDGRVSNVRILSAEPRNMFEREVKQAMRKWRYEAKEAKDRTVNIRFK
INGTTEMN