Protein Info for IAI46_14030 in Serratia liquefaciens MT49

Annotation: anthranilate phosphoribosyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02885: Glycos_trans_3N
  • amino acids 3 to 62 (60 residues), 59.2 bits, E=2.7e-20
• TIGR01245: anthranilate phosphoribosyltransferase
  • amino acids 5 to 329 (325 residues), 425.1 bits, E=1e-131
• PF00591: Glycos_transf_3
  • amino acids 72 to 322 (251 residues), 345.1 bits, E=2.8e-107

Best Hits

Swiss-Prot: 97% identical to TRPD_SERP5: Anthranilate phosphoribosyltransferase (trpD) from Serratia proteamaculans (strain 568)

KEGG orthology group: K00766, anthranilate phosphoribosyltransferase [EC: 2.4.2.18] (inferred from 97% identity to spe:Spro_2669)

Predicted SEED Role

"Anthranilate phosphoribosyltransferase (EC 2.4.2.18)" in subsystem Auxin biosynthesis or Tryptophan synthesis (EC 2.4.2.18)

MetaCyc Pathways

• superpathway of chorismate metabolism (54/59 steps found)
• superpathway of aromatic amino acid biosynthesis (18/18 steps found)
• superpathway of L-tryptophan biosynthesis (13/13 steps found)
• L-tryptophan biosynthesis (6/6 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from shikimate pathway
• Biosynthesis of phenylpropanoids
• Biosynthesis of plant hormones
• Phenylalanine, tyrosine and tryptophan biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 2.4.2.18

Use Curated BLAST to search for 2.4.2.18

Protein Sequence (332 amino acids)

>IAI46_14030 anthranilate phosphoribosyltransferase (Serratia liquefaciens MT49)
MQTILEKLYRSESMNQQESQQLFSAIVRGELEPSQLAAALISMKIRGERPEEIAGAAKAL
LADALPFPRPDYPFADIVGTGGDGTNSINISTASAFVAAACGAKVAKHGNRSVSSRSGSS
DLLAAFGIRLDLPAEQARQALDDLGVCFLFAPQYHTGFRHAMPVRQQLKTRTVFNVLGPL
INPARPPLALIGVYSPELVLPIAETLRVLGYQRAAVVHGGGMDEVAIHTATHVAELNNGE
IESYQLTPESFGLQRYPLEALLGGSPEENRDILARLLQGKGDPAHAAAVAANVALLLKLF
GHEDLRKNAQQALDMIHSGKAYERVTALAAKG