Protein Info for IAI46_13945 in Serratia liquefaciens MT49

Annotation: GTP cyclohydrolase II

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00505: GTP cyclohydrolase II
  • amino acids 5 to 194 (190 residues), 302.2 bits, E=6.4e-95
• PF00925: GTP_cyclohydro2
  • amino acids 5 to 170 (166 residues), 227 bits, E=5.1e-72

Best Hits

Swiss-Prot: 95% identical to RIBA_ESCF3: GTP cyclohydrolase-2 (ribA) from Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73)

KEGG orthology group: K01497, GTP cyclohydrolase II [EC: 3.5.4.25] (inferred from 100% identity to spe:Spro_2653)

MetaCyc: 91% identical to GTP cyclohydrolase 2 (Escherichia coli K-12 substr. MG1655)
GTP cyclohydrolase II. [EC: 3.5.4.25]

Predicted SEED Role

"GTP cyclohydrolase II (EC 3.5.4.25)" in subsystem Molybdenum cofactor biosynthesis or Riboflavin, FMN and FAD metabolism (EC 3.5.4.25)

MetaCyc Pathways

• flavin biosynthesis I (bacteria and plants) (9/9 steps found)
• flavin biosynthesis III (fungi) (8/9 steps found)
• 6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia) (3/5 steps found)
• toxoflavin biosynthesis (4/7 steps found)
• flavin biosynthesis II (archaea) (6/10 steps found)

KEGG Metabolic Maps

• Riboflavin metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.5.4.25

Protein Sequence (197 amino acids)

>IAI46_13945 GTP cyclohydrolase II (Serratia liquefaciens MT49)
MQLKRVAEAKLPTPWGDFLMVGFEELATGHDHLALVFGDISGATPVLSRVHSECLTGDAL
FSLRCDCGFQLEAALEHIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDKGADTVEANHQ
LGFAADERDFTLCADMFKLLGVDAVRLLTNNPKKVEILTEAGINITERVPLIVGRNPKNE
RYLATKAAKMGHLLDQK