Protein Info for IAI46_13395 in Serratia liquefaciens MT49

Annotation: copper-translocating P-type ATPase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 846 transmembrane" amino acids 177 to 196 (20 residues), see Phobius details amino acids 215 to 234 (20 residues), see Phobius details amino acids 251 to 272 (22 residues), see Phobius details amino acids 279 to 298 (20 residues), see Phobius details amino acids 432 to 454 (23 residues), see Phobius details amino acids 460 to 482 (23 residues), see Phobius details amino acids 776 to 795 (20 residues), see Phobius details amino acids 801 to 823 (23 residues), see Phobius details TIGR00003: copper ion binding protein" amino acids 20 to 81 (62 residues), 38.9 bits, see alignment 2e-13 amino acids 87 to 149 (63 residues), 37.9 bits, see alignment 4.2e-13 PF00403: HMA" amino acids 22 to 79 (58 residues), 55.5 bits, see alignment 1.2e-18 amino acids 90 to 148 (59 residues), 53.5 bits, see alignment 5.3e-18 TIGR01511: copper-translocating P-type ATPase" amino acids 230 to 826 (597 residues), 598.2 bits, see alignment E=4.4e-183 TIGR01525: heavy metal translocating P-type ATPase" amino acids 248 to 825 (578 residues), 639.4 bits, see alignment E=1.6e-195 TIGR01494: HAD ATPase, P-type, family IC" amino acids 287 to 794 (508 residues), 307.8 bits, see alignment E=2.6e-95 PF00122: E1-E2_ATPase" amino acids 316 to 496 (181 residues), 199.2 bits, see alignment E=8.6e-63 PF00702: Hydrolase" amino acids 514 to 730 (217 residues), 135.2 bits, see alignment E=7.4e-43 PF08282: Hydrolase_3" amino acids 703 to 762 (60 residues), 25.6 bits, see alignment 1.9e-09

Best Hits

Swiss-Prot: 68% identical to ATCU_SINMW: Copper-transporting P-type ATPase (actP) from Sinorhizobium medicae (strain WSM419)

KEGG orthology group: K01533, Cu2+-exporting ATPase [EC: 3.6.3.4] (inferred from 88% identity to spe:Spro_2413)

Predicted SEED Role

"Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.3, EC 3.6.3.4, EC 3.6.3.5)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.3, 3.6.3.4, 3.6.3.5

Use Curated BLAST to search for 3.6.3.3 or 3.6.3.4 or 3.6.3.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (846 amino acids)

>IAI46_13395 copper-translocating P-type ATPase (Serratia liquefaciens MT49)
MTSVSVQQGANSALRTTRLSLPVEGMTCASCVGRVERALKAVPGVQTATVNLATERADIT
FGDRADPQAAVGAIESAGYAVREETTELGIEDMTCASCVGRVEKALRQIPGVIEANVNLA
TERARVRHSAGLVTTAMLEAAVEQAGYKARRLSAATASSDDQDSERRENEARGLRRSLLI
AALLTLPVFVLEMGSHLIPAMHHWVLGVLGEQRNGYLQFVLTTLVLFGPGLRFFRKGVPA
LLRGAPDMNSLVSVGTAAAYGYSVVATFIPQVLPQGTANIYFEAAAVIVTLILLGRTLEA
RAKGRTSQAIKRLVGLQAKTARVERNGETLEIPLDQVTTGDVVFVRPGEKIPVDGQVVEG
ASYVDESMITGEPVPVSKSVGAEVVGGTINKTGAFSFRVTKVGANTVLAQIIRLVEEAQG
SKLPIQALVDKVTLWFVPAVMAAAALTFLIWLIFGPTPALTFALVNAVAVLIIACPCAMG
LATPTSIMVGTGRAAELGVLFRKGEALQALRDVSVIALDKTGTLTKGRPELTDLVPAEGF
DYDEVLALVAAVETRSEHPIAEAIVAAAKQRDIKIAAIEAFDATPGFGVSAKVSGRTVSV
GADRFMTQLGLDVASFLPAAQRLGEQGKSPLYAAIDGRLAAVIAVADPIKETTPEAIKAL
HALGLKVAMITGDNAATASAIARQLGIDEVAAEVLPDGKVAALKQFRSHGARVAFVGDGI
NDAPALAEADVGLAIGTGTDVAIEAADVVLMSGDLRGVANAIALSQATIRNIKQNLFWAF
AYNAVLIPVAAGMLYPINGTLLSPIFAAAAMALSSVFVLGNALRLKRFQAPMGIESRPVG
PENVKV