Protein Info for IAI46_13390 in Serratia liquefaciens MT49

Annotation: TolC family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 498 signal peptide" amino acids 1 to 24 (24 residues), see Phobius details TIGR01845: efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family" amino acids 14 to 468 (455 residues), 282.6 bits, see alignment E=2.9e-88 PF02321: OEP" amino acids 69 to 256 (188 residues), 50.7 bits, see alignment E=9.9e-18 amino acids 286 to 466 (181 residues), 70.5 bits, see alignment E=8.5e-24

Best Hits

KEGG orthology group: None (inferred from 70% identity to pap:PSPA7_1626)

Predicted SEED Role

"RND efflux system, outer membrane lipoprotein CmeC" in subsystem Multidrug Resistance Efflux Pumps or Multidrug efflux pump in Campylobacter jejuni (CmeABC operon)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (498 amino acids)

>IAI46_13390 TolC family protein (Serratia liquefaciens MT49)
MKSLYQSLWFPLSALTLLTGCSSVGPDYSPPSLSSARLPASFGEASPGLNSAAVEVEWWR
AFDDPILSGLIRQALSVNHDIGIAAMRLEEAKALLREDRQSFLPSGGPAFSYENRRKSER
ETSPDQARQQETYRGAVDSAWEIDLFGRVRRSVEEAQAQAGSSEALLRDVQAGVAAAVAA
TWFELCGIEAELAIVEDITRSQRESLAQVERLANAGSASEFDRLRAEALLRNVEVVAPEL
ERRRAVSVNALAVLLGETPQRFSPPVAIPGRDELKVTSLAVGNPEALLARRADIAAAERT
LAAATARIGIETAGLYPEIQIQGSIGFVAGNLDAVNGAGALSGFILPVIRWSLLDNGRVR
ARIAASEARAQEALLLYDQTLLRALQETDDAFKTYKATGSTLELRLLESAANREAARLAR
LQFSQGQGLYLEVLDAERSDFNSRRALAVARTEQQLAVVSIYKALGGGWQVCTVETTLCG
GAKTRPNLPLAKQIPDRS