Protein Info for IAI46_13230 in Serratia liquefaciens MT49

Annotation: SIS domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR02815: putative sugar isomerase, AgaS family
  • amino acids 16 to 383 (368 residues), 542.5 bits, E=2.5e-167
• PF01380: SIS
  • amino acids 53 to 190 (138 residues), 36.2 bits, E=2.5e-13

Best Hits

KEGG orthology group: K02082, tagatose-6-phosphate ketose/aldose isomerase [EC: 5.-.-.-] (inferred from 94% identity to spe:Spro_2578)

Predicted SEED Role

"Galactosamine-6-phosphate isomerase (EC 5.3.1.-)" in subsystem N-Acetyl-Galactosamine and Galactosamine Utilization (EC 5.3.1.-)

KEGG Metabolic Maps

• Biosynthesis of ansamycins
• Biosynthesis of steroids
• Carotenoid biosynthesis - General
• Galactose metabolism
• Inositol phosphate metabolism
• Lipopolysaccharide biosynthesis
• Pentose and glucuronate interconversions

Isozymes

Compare fitness of predicted isozymes for: 5.-.-.-, 5.3.1.-

Use Curated BLAST to search for 5.-.-.- or 5.3.1.-

Protein Sequence (388 amino acids)

>IAI46_13230 SIS domain-containing protein (Serratia liquefaciens MT49)
MNGYFAYDAGWLEQRHALHTAREIWQQPDLWDALHRQLQEQQALWQPFLAPLLANPRLQI
VLCGAGSSAFAGRALAPWLREKTGRDVVAYGTTDIVANPHQYLDLTRPTLLVSFARSGNS
PESVATVELADQLLPESYHLMLVCNPDSQLAHYAHQRENVCSLVMPQGSNDQSFAMTSSF
SCMMLSAALLLGPHSLSEAQRPLATMVARCRELRETLQPQVKAFAASGFRRYITLGGSCF
TGLAEEASLKMLELTAGQIVTRYDSPLGLRHGPKFMVDDQTLVLLMFSSDDYARQYDRDL
WNELHRDGLAMQMVGLTGSAQPVSDMMLNLHHAEDDVWLLFPYLLFTQMLAFESSLALGM
TPDNPCPTGEVNRVVKGVTIYRYPSSVA