Protein Info for IAI46_12975 in Serratia liquefaciens MT49

Annotation: mechanosensitive ion channel family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 808 signal peptide" amino acids 1 to 28 (28 residues), see Phobius details transmembrane" amino acids 212 to 232 (21 residues), see Phobius details amino acids 253 to 274 (22 residues), see Phobius details amino acids 294 to 312 (19 residues), see Phobius details amino acids 332 to 352 (21 residues), see Phobius details amino acids 364 to 383 (20 residues), see Phobius details amino acids 408 to 432 (25 residues), see Phobius details amino acids 439 to 464 (26 residues), see Phobius details amino acids 485 to 509 (25 residues), see Phobius details amino acids 539 to 560 (22 residues), see Phobius details amino acids 581 to 604 (24 residues), see Phobius details amino acids 610 to 629 (20 residues), see Phobius details PF12607: DUF3772" amino acids 137 to 194 (58 residues), 49.7 bits, see alignment 3.7e-17 PF00924: MS_channel_2nd" amino acids 628 to 693 (66 residues), 76.6 bits, see alignment E=1.9e-25 PF21082: MS_channel_3rd" amino acids 701 to 783 (83 residues), 28.6 bits, see alignment E=2.3e-10

Best Hits

KEGG orthology group: None (inferred from 90% identity to spe:Spro_2528)

Predicted SEED Role

"potassium efflux system KefA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (808 amino acids)

>IAI46_12975 mechanosensitive ion channel family protein (Serratia liquefaciens MT49)
MLKPRQIILFLFLLFGLQLAPLTSVAAQDDSPVAESQPDPATALKNYQKQLDSIKQQVSK
ASNDTQLSKLKLTTDDLAAKLEKLAADLQPAQEKLQAQLDVLGPQPAAGALAENAAVVQQ
RNALNNSKKQLDEAVQRAQAMRAGVLDLGQQISDLRRVAFKSQLALNTGSVLGTKFWTPV
IKPADDDVQRLDQFNAAMKQTWDASWQEDSRYGTLGLLVLAVVIWSWGRYFSERFLAWVS
IRYLPDGRLRRSFMAIMTVTVTVVTTSIALNLLFLTFTRVQPLPVMLEDFAGSFYQLGIF
CALIAGLGRATLSLNRPSWRLGTLDNAVASGLRYFSPLLAGLALAFGTVELINNAVSASL
STTIFGNGLVAGLIGMVLLAMPLRSQRIRRQLEQQGEHVEKRSTISGLLHMSTLVCSSVI
LLSLLIGYIAFARFLTYQVIWIALVLMTFYFLVLFATDLCAAIFSPQTASGKMLKKSLNF
KDRHLEQMAIIFTAIAKCSLLLLMIVSLFNGSFGTTTPNSLLEKIIAILSGEGLKQLNIV
PGNLINAVICLAIGIYILRVTQRWLSQELLPKTIADIGIRASLVTLFSNVGYVLLILITL
AALGIQWNNLAWIVSALSVGIGFGLQEIVKNFISGLILLTERPVKVGDMIGIGGVEGDVR
RINVRATEIQLSDRSTMIVPNSQLISQNVRNATMGNAQGVVTIALTFPTDIDPEQVRNIL
LSAYQEYEAILDAPAPYVRFSQLGPDGIILSVTGYVASPRMVGSTKSELLFNILKLLRAH
RVNMSSPQEVVFMKQQAKNLANEEEQSS