Protein Info for IAI46_12865 in Serratia liquefaciens MT49

Annotation: myo-inosose-2 dehydratase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR04379: myo-inosose-2 dehydratase
  • amino acids 5 to 290 (286 residues), 409.7 bits, E=3.9e-127
• PF01261: AP_endonuc_2
  • amino acids 38 to 282 (245 residues), 94.7 bits, E=3.8e-31

Best Hits

Swiss-Prot: 47% identical to MOCC_RHIML: Rhizopine catabolism protein MocC (mocC) from Rhizobium meliloti

KEGG orthology group: K03335, inosose dehydratase [EC: 4.2.1.44] (inferred from 80% identity to pao:Pat9b_4547)

Predicted SEED Role

"Inosose dehydratase (EC 4.2.1.44)" in subsystem Inositol catabolism (EC 4.2.1.44)

MetaCyc Pathways

• myo-inositol degradation I (6/7 steps found)
• myo-, chiro- and scyllo-inositol degradation (6/10 steps found)

KEGG Metabolic Maps

• Inositol phosphate metabolism

Isozymes

Compare fitness of predicted isozymes for: 4.2.1.44

Use Curated BLAST to search for 4.2.1.44

Protein Sequence (304 amino acids)

>IAI46_12865 myo-inosose-2 dehydratase (Serratia liquefaciens MT49)
MVLKAKLGIAPIAWSNDDLPQLGGETSLATCLFESHLAGFQGVETGGKFPKTSEELKPTL
KYFQLELVSGWYSGTLLDNSLNEEISRSLPQMQLFRDCGAACLVYGETAGTIQNRQNVPL
AERRRLSDAEISEYGDKLSRFAAFCKDFGVPLAFHHHMGTAIEDEQDIDRLMAATSKDVG
LLFDTGHLVFAGVDPVRVLEKHGDRIIHVHTKDVRSDVLNGIDRHKDSFLDAVLKGVYTV
PGDGSIDFTAVINKLAAIGYQGWFVVEAEQDPAKAPPLEYARLGYNTLCKALSAAGYRYT
EGDI