Protein Info for IAI46_12835 in Serratia liquefaciens MT49

Annotation: inositol 2-dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR04380: inositol 2-dehydrogenase
  • amino acids 1 to 328 (328 residues), 400.1 bits, E=3e-124
• PF01408: GFO_IDH_MocA
  • amino acids 2 to 120 (119 residues), 85.6 bits, E=4.4e-28
• PF02894: GFO_IDH_MocA_C
  • amino acids 133 to 329 (197 residues), 89.4 bits, E=3.1e-29

Best Hits

KEGG orthology group: K00010, myo-inositol 2-dehydrogenase [EC: 1.1.1.18] (inferred from 60% identity to pao:Pat9b_4536)

Predicted SEED Role

"Myo-inositol 2-dehydrogenase (EC 1.1.1.18)" in subsystem Inositol catabolism (EC 1.1.1.18)

MetaCyc Pathways

• myo-inositol degradation I (6/7 steps found)
• myo-, chiro- and scyllo-inositol degradation (6/10 steps found)
• myo-inositol degradation II (1/5 steps found)
• streptomycin biosynthesis (2/18 steps found)

KEGG Metabolic Maps

• Inositol phosphate metabolism
• Streptomycin biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.18

Use Curated BLAST to search for 1.1.1.18

Protein Sequence (331 amino acids)

>IAI46_12835 inositol 2-dehydrogenase (Serratia liquefaciens MT49)
MIRIAILGAGRIGQVHAANVARHNDAFLAAVADPVIENAQALTAAWGGVALADPVEAIQN
PDIDAVIIGTPTHTHIDLMLAAAKAGKAVLCEKPVDLDITKAYAAQRALGEHASQVMLGF
NRRFDLGFSEINQRIRSGDIGDLHQVIITSRDPGLAPMGYLKNSGGIFRDMVIHDFDLAR
WILGEEPVEVFATGSRLFAPELEALGDYDTVMVQLRTASGKQCQINCSRQAIYGYDQRME
VFGSGGMLLNDNLRATPVRRYSRQETEARGPLLNFFMERYSDAYRLEIDAFISAIKQGTP
MPITVHDGCMALRLADAAQLSADTHAAVALD