Protein Info for IAI46_12470 in Serratia liquefaciens MT49

Annotation: VOC family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00903: Glyoxalase
  • amino acids 19 to 126 (108 residues), 26.9 bits, E=2.8e-10
  • amino acids 150 to 266 (117 residues), 62.1 bits, E=3.4e-21

Best Hits

KEGG orthology group: K00446, catechol 2,3-dioxygenase [EC: 1.13.11.2] (inferred from 50% identity to rec:RHECIAT_CH0002315)

Predicted SEED Role

No annotation

MetaCyc Pathways

• catechol degradation II (meta-cleavage pathway) (6/7 steps found)
• catechol degradation I (meta-cleavage pathway) (4/5 steps found)
• catechol degradation to 2-hydroxypentadienoate II (3/4 steps found)
• catechol degradation to 2-hydroxypentadienoate I (1/2 steps found)
• toluene degradation I (aerobic) (via o-cresol) (4/7 steps found)
• toluene degradation V (aerobic) (via toluene-cis-diol) (4/7 steps found)
• 2-nitrotoluene degradation (1/3 steps found)
• meta cleavage pathway of aromatic compounds (6/10 steps found)
• toluene degradation to 2-hydroxypentadienoate (via toluene-cis-diol) (1/4 steps found)
• toluene degradation to 2-hydroxypentadienoate I (via o-cresol) (1/4 steps found)
• toluene degradation II (aerobic) (via 4-methylcatechol) (2/6 steps found)
• toluene degradation IV (aerobic) (via catechol) (6/13 steps found)
• naphthalene degradation to acetyl-CoA (5/12 steps found)
• mandelate degradation to acetyl-CoA (7/18 steps found)
• superpathway of aerobic toluene degradation (14/30 steps found)
• superpathway of aromatic compound degradation via 3-oxoadipate (15/35 steps found)
• superpathway of aromatic compound degradation via 2-hydroxypentadienoate (14/42 steps found)

KEGG Metabolic Maps

• 1,4-Dichlorobenzene degradation
• Benzoate degradation via hydroxylation
• Carbazole degradation
• Styrene degradation
• Toluene and xylene degradation

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.13.11.2

Protein Sequence (332 amino acids)

>IAI46_12470 VOC family protein (Serratia liquefaciens MT49)
MTTLPLTEYDPPFSITRASHLVLTSRDLAASELFYTQVIGMVLTHREEDRLYLRGLEEAC
HHSLVIKLSKAEPHCERVGLRVFREKDLELAKLFLDQQGLENCWAEVPFQGRTLHFTDPT
GTLIELCASMPVVPRLHHQVHLYRGGSAQRLDHFQLHTPHVQRAAEFYMTKLGFRATDIY
FNEGGMGAAFLQRKGNTQDLVYLHGPGPRLHHFGYTIPDSQEILRACDTAGNLGFGSSIE
RGPGRHGMGHVLYVYLRDPDGHRIELHNTPYQIIDIELETNILAPDQRQQLLPWGLPPQR
KWVTEASAFANTPVEPTTEGYPLVLEEYLSRQ