Protein Info for IAI46_12465 in Serratia liquefaciens MT49

Annotation: aldehyde dehydrogenase family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 495 transmembrane" amino acids 167 to 179 (13 residues), see Phobius details PF00171: Aldedh" amino acids 33 to 491 (459 residues), 537.4 bits, see alignment E=1.3e-165

Best Hits

Swiss-Prot: 48% identical to FEAB_ECOLI: Phenylacetaldehyde dehydrogenase (feaB) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 58% identity to pmk:MDS_2856)

MetaCyc: 58% identical to 4-hydroxyphenylacetaldehyde dehydrogenase (Pseudomonas putida U)
4-hydroxyphenylacetaldehyde dehydrogenase. [EC: 1.2.1.53]

Predicted SEED Role

"Aldehyde dehydrogenase (EC 1.2.1.3)" in subsystem Entner-Doudoroff Pathway or Glycerolipid and Glycerophospholipid Metabolism in Bacteria or Methylglyoxal Metabolism or Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate (EC 1.2.1.3)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.3

Use Curated BLAST to search for 1.2.1.3 or 1.2.1.53

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (495 amino acids)

>IAI46_12465 aldehyde dehydrogenase family protein (Serratia liquefaciens MT49)
MADIKVLPQVSAFLAQEHGQFIDGQLIPAAGGQRLPVVNPANGQTIANVAGATADEVEQA
MQSADRALKGEWGKSLPAQRQQILLRFADLLEAHREEIAQLETLTNGKLIGSSRLFEVDH
TCVFIRYYAGWATKLHGETLAPSIPSFNGERYTAMTYREPVGVVAAIIPWNFPVMIAIWK
IAAALCTGCCIVVKPSEFAPLTLLRLAQLAHQAGVPAGVFNVVNGERQVGQWLIEHPRVN
KVSFTGSVPAGIAIGQAAIKADLTRITLELGGKNPAAFLADVDTQRAVDGIMLAGLVHQG
QVCSSAERFYIHASRFDEIVEQVIARVEALKIGSPMDEATQYGPLANQAHFNRIKAMFDQ
AHSHDQVLSGGTVLDGEGFYVTPTVIRATGQDDPLMREEAFAGVLSFMPFEDEEQLLHLM
NDSSYGLSASIWTNDFSKAMDLMRRIEAGMVWVNSHTIMDPAVPFGGMKASGIGREFGSA
FIESYTELKSVIMCY