Protein Info for IAI46_11600 in Serratia liquefaciens MT49

Annotation: PTS maltose transporter subunit IICB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 539 transmembrane" amino acids 21 to 42 (22 residues), see Phobius details amino acids 62 to 88 (27 residues), see Phobius details amino acids 96 to 118 (23 residues), see Phobius details amino acids 138 to 161 (24 residues), see Phobius details amino acids 182 to 202 (21 residues), see Phobius details amino acids 204 to 205 (2 residues), see Phobius details amino acids 209 to 227 (19 residues), see Phobius details amino acids 234 to 247 (14 residues), see Phobius details amino acids 295 to 312 (18 residues), see Phobius details amino acids 324 to 348 (25 residues), see Phobius details amino acids 351 to 375 (25 residues), see Phobius details amino acids 396 to 415 (20 residues), see Phobius details TIGR02004: PTS system, maltose and glucose-specific IIBC component" amino acids 8 to 523 (516 residues), 856.4 bits, see alignment E=6.9e-262 PF02378: PTS_EIIC" amino acids 19 to 361 (343 residues), 279.9 bits, see alignment E=2.6e-87 TIGR00826: PTS system, glucose-like IIB component" amino acids 421 to 510 (90 residues), 84.8 bits, see alignment E=4e-28 PF00367: PTS_EIIB" amino acids 453 to 485 (33 residues), 57.1 bits, see alignment (E = 9.6e-20)

Best Hits

Swiss-Prot: 81% identical to PTOCB_ECOLI: PTS system maltose-specific EIICB component (malX) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 97% identity to srr:SerAS9_2217)

MetaCyc: 81% identical to PTS enzyme IIBC component MalX (Escherichia coli K-12 substr. MG1655)
TRANS-RXN0-574; TRANS-RXN0-575

Predicted SEED Role

"PTS system, maltose and glucose-specific IIC component (EC 2.7.1.69) / PTS system, maltose and glucose-specific IIB component (EC 2.7.1.69)" in subsystem Maltose and Maltodextrin Utilization (EC 2.7.1.69)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.1.69

Use Curated BLAST to search for 2.7.1.69

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (539 amino acids)

>IAI46_11600 PTS maltose transporter subunit IICB (Serratia liquefaciens MT49)
MPAPKKQKITLWEFFQSLGKTFMLPVALLSFCGIMLGIGSSLSSRDVITLMPFIGHPAFQ
LLFTWMSKIGSFAFSFLPVMFAIAIPLGMARENKGVAAFSGFVGFAVLNLATNFYLTTAG
ILPTTDPLVLKANNIQNILGIQSIDTGILGAVIVGIIVYLLHERFNTIRLPDALAFFGGT
RFVPIVTTLVLGLCGLVIPLIWPWFAAGINGLGWVINGAGAFGPMIFGTGERLLLPFGLH
HILVALIRFTEAGGTLDVCGHSVSGALTIFQAQLSCPTTTGFAESATRFLSQGKMPAFLG
GLPGAALAMYHCAKPENRHKIKGLLISGVVACVVGGTTEPIEFLFLFVAPFLYFIHAILT
GLGFTVMALLGVTIGNTDGNIIDFVVFGILHGTATKWYLVPIVAAIWFAAYYAIFRFSIQ
RFNIKTPGRESETAGSQSAPVGAVGKSGYNVPAILAALGGSENIVSLDNCITRLRLSVDD
MSKVDDAALKANRAIGVVHLNEHNLQVVIGPQVQSVKDELDSLIAAAQPAAALQGASHV