Protein Info for IAI46_11540 in Serratia liquefaciens MT49

Annotation: adenosine deaminase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01430: adenosine deaminase
  • amino acids 6 to 330 (325 residues), 367.6 bits, E=2.5e-114
• PF00962: A_deaminase
  • amino acids 7 to 331 (325 residues), 403.6 bits, E=3.1e-125

Best Hits

Swiss-Prot: 96% identical to ADD_SERP5: Adenosine deaminase (add) from Serratia proteamaculans (strain 568)

KEGG orthology group: K01488, adenosine deaminase [EC: 3.5.4.4] (inferred from 97% identity to srs:SerAS12_2205)

MetaCyc: 79% identical to adenosine deaminase (Escherichia coli K-12 substr. MG1655)
Adenosine deaminase. [EC: 3.5.4.4]; 3.5.4.4 [EC: 3.5.4.4]

Predicted SEED Role

"Adenosine deaminase (EC 3.5.4.4)" in subsystem Purine conversions (EC 3.5.4.4)

MetaCyc Pathways

• purine nucleotides degradation II (aerobic) (11/11 steps found)
• superpathway of purine deoxyribonucleosides degradation (7/7 steps found)
• purine ribonucleosides degradation (6/6 steps found)
• adenosine nucleotides degradation II (5/5 steps found)
• adenine and adenosine salvage III (4/4 steps found)
• purine deoxyribonucleosides degradation I (4/4 steps found)
• adenine and adenosine salvage V (3/3 steps found)
• purine deoxyribonucleosides degradation II (3/3 steps found)

KEGG Metabolic Maps

• Purine metabolism

Isozymes

Compare fitness of predicted isozymes for: 3.5.4.4

Use Curated BLAST to search for 3.5.4.4

Protein Sequence (332 amino acids)

>IAI46_11540 adenosine deaminase (Serratia liquefaciens MT49)
MIDPRLPLTDIHRHLDGNIRAQTILDLGRQFNLALPANELEALRPHVQITHAEPDLVSFL
QKLDWGVAVLGDLDACRRVAYENVEDAANAGLHYAELRFSPYYMAMKHQLPVAGVVEAVI
DGVRSGSRDLGIDVRLIGIMSRTFGEAACLQELEGLLAHRDGITALDLAGDELGFPGSLF
LSHFNRARDAGLRITVHAGEAAGPESIWQAIRELGAERIGHGVKAIEDPALMDFLAEHGI
GIESCLTSNIQTSTVPSLAQHPLAKFLRHGVMASINTDDPAVQGIEIEHEYRVAAPQAGL
TPAEIRTAQENGLKMAFLSEQEKQALRDKVQG