Protein Info for IAI46_11360 in Serratia liquefaciens MT49

Annotation: pyridoxamine 5'-phosphate oxidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00558: pyridoxamine 5'-phosphate oxidase
  • amino acids 4 to 217 (214 residues), 314.1 bits, E=2.3e-98
• PF01243: Putative_PNPOx
  • amino acids 38 to 121 (84 residues), 87.2 bits, E=6.9e-29
• PF10590: PNP_phzG_C
  • amino acids 177 to 217 (41 residues), 72 bits, 3.1e-24

Best Hits

Swiss-Prot: 98% identical to PDXH_SERP5: Pyridoxine/pyridoxamine 5'-phosphate oxidase (pdxH) from Serratia proteamaculans (strain 568)

KEGG orthology group: K00275, pyridoxamine 5'-phosphate oxidase [EC: 1.4.3.5] (inferred from 98% identity to spe:Spro_2218)

MetaCyc: 79% identical to pyridoxine/pyridoxamine 5'-phosphate oxidase (Escherichia coli K-12 substr. MG1655)
Pyridoxal 5'-phosphate synthase. [EC: 1.4.3.5]; 1.4.3.5 [EC: 1.4.3.5]

Predicted SEED Role

"Pyridoxamine 5'-phosphate oxidase (EC 1.4.3.5)" in subsystem Pyridoxin (Vitamin B6) Biosynthesis (EC 1.4.3.5)

MetaCyc Pathways

• superpathway of pyridoxal 5'-phosphate biosynthesis and salvage (11/12 steps found)
• pyridoxal 5'-phosphate biosynthesis I (7/7 steps found)
• pyridoxal 5'-phosphate salvage I (5/6 steps found)
• pyridoxal 5'-phosphate salvage II (plants) (7/9 steps found)
• 4-amino-2-methyl-5-diphosphomethylpyrimidine biosynthesis II (4/8 steps found)

KEGG Metabolic Maps

• Vitamin B6 metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.4.3.5

Protein Sequence (217 amino acids)

>IAI46_11360 pyridoxamine 5'-phosphate oxidase (Serratia liquefaciens MT49)
MIENNEFDVADLRREYTRGGLRRNDLTANPLELFEKWLKQACDARLADPTAMCVATVDEN
GQPYQRIVLLKHVDEKGLVFYTNLGSRKAQQLANNPHISLLFPWHMLDRQVIFLGKAERL
STLEVMKYFASRPKDSQIGAWVSQQSSRISARGVLESKFLELKQKFQQGEVPLPSFWGGF
RVNFDSVEFWQGGANRLHDRFLYQRDGNDWKIDRLAP