Protein Info for IAI46_11285 in Serratia liquefaciens MT49

Annotation: TetR/AcrR family transcriptional regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 206 PF00440: TetR_N" amino acids 30 to 65 (36 residues), 32.1 bits, see alignment 7.7e-12 PF16925: TetR_C_13" amino acids 92 to 194 (103 residues), 49.2 bits, see alignment E=4.7e-17

Best Hits

Swiss-Prot: 52% identical to NEMR_ECOLI: HTH-type transcriptional repressor NemR (nemR) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 93% identity to spe:Spro_2203)

Predicted SEED Role

"Transcriptional regulator, TetR family"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (206 amino acids)

>IAI46_11285 TetR/AcrR family transcriptional regulator (Serratia liquefaciens MT49)
MLTAIMTKHAHCPTDTREHLLATGETLSLRLGFTGMGLSELLNTAGVPKGSFYHYFRSKE
AFGEAMLQRYFEHYDGQMKQLFADDKSDARHQLLSYYAQAISYHCRSECHNACLAVKLSA
EVSDLSEPMRHALETGTARVIAHLQDAIERGIREGALSIAMSPAATAETLYSLWLGASLR
AKIRRSVAPLTSTLESIELLLRPPQP