Protein Info for IAI46_11230 in Serratia liquefaciens MT49

Annotation: Bcr/CflA family multidrug efflux MFS transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 403 transmembrane" amino acids 7 to 26 (20 residues), see Phobius details amino acids 38 to 61 (24 residues), see Phobius details amino acids 73 to 91 (19 residues), see Phobius details amino acids 98 to 119 (22 residues), see Phobius details amino acids 131 to 153 (23 residues), see Phobius details amino acids 159 to 180 (22 residues), see Phobius details amino acids 208 to 231 (24 residues), see Phobius details amino acids 245 to 261 (17 residues), see Phobius details amino acids 273 to 292 (20 residues), see Phobius details amino acids 302 to 325 (24 residues), see Phobius details amino acids 337 to 358 (22 residues), see Phobius details amino acids 363 to 382 (20 residues), see Phobius details TIGR00710: drug resistance transporter, Bcr/CflA subfamily" amino acids 4 to 382 (379 residues), 370.2 bits, see alignment E=8.5e-115 PF07690: MFS_1" amino acids 12 to 344 (333 residues), 151.4 bits, see alignment E=3.3e-48 PF00083: Sugar_tr" amino acids 39 to 184 (146 residues), 31.8 bits, see alignment E=7.5e-12

Best Hits

Swiss-Prot: 66% identical to YDHC_ECOLI: Inner membrane transport protein YdhC (ydhC) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 93% identity to spe:Spro_2193)

MetaCyc: 66% identical to purine nucleoside transporter PunC (Escherichia coli K-12 substr. MG1655)
TRANS-RXN0-631

Predicted SEED Role

"Putative transport protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (403 amino acids)

>IAI46_11230 Bcr/CflA family multidrug efflux MFS transporter (Serratia liquefaciens MT49)
MRNSFGFMFYLAGLSMLGYLATDMYLPAFGMMQQDLQISAGAISASLSIFLAGFAFAQLL
WGPLSDRLGRKPVLLIGLALFALGCLGMLWVQNAVQLWSLRFIQAIGVCSAAVTWQALVI
DRYREGKANRVFATIMPLVALSPALAPLVGAWLLNHMGWRAIFAVLLGITVLLLLPTLLL
KESAKTVPSDDNKKSALSFFQLLKSRIFSGNVMIFAACSAGFFAWLTGSPFILGDMGYSP
NDIGLSYVPQTLAFLLGGYGCRTALNRMNGNTLLPWLLVVYGVSMVALYLVATLTQPTLT
TLLIPFCVMALVNGAIYPIVVANALTPFPEGTGKAAALQNTLQLGLCFVASMLVSAFIAQ
PLLATVTVMVSTVVLAALGYLMQRRKVMDDRQATRQEHANSAS