Protein Info for IAI46_11015 in Serratia liquefaciens MT49

Annotation: UDP-4-amino-4-deoxy-L-arabinose aminotransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01041: DegT_DnrJ_EryC1
  • amino acids 11 to 373 (363 residues), 431.4 bits, E=4.7e-133
• PF01212: Beta_elim_lyase
  • amino acids 33 to 210 (178 residues), 30.9 bits, E=2.7e-11
• PF00155: Aminotran_1_2
  • amino acids 37 to 162 (126 residues), 37.4 bits, E=2.8e-13

Best Hits

Swiss-Prot: 97% identical to ARNB_SERP5: UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase (arnB) from Serratia proteamaculans (strain 568)

KEGG orthology group: K07806, UDP-4-amino-4-deoxy-L-arabinose-oxoglutarate aminotransferase [EC: 2.6.1.87] (inferred from 97% identity to spe:Spro_2154)

MetaCyc: 70% identical to UDP-4-amino-4-deoxy-L-arabinose aminotransferase (Escherichia coli K-12 substr. MG1655)
RXN0-1863 [EC: 2.6.1.87, 2.6.1.92]

Predicted SEED Role

"UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase (EC 2.6.1.-)" in subsystem Lipid A-Ara4N pathway ( Polymyxin resistance ) (EC 2.6.1.-)

MetaCyc Pathways

• polymyxin resistance (4/6 steps found)

KEGG Metabolic Maps

• Aminophosphonate metabolism
• Arginine and proline metabolism
• Caprolactam degradation
• Lysine biosynthesis
• Lysine degradation
• Methionine metabolism
• Nucleotide sugars metabolism

Isozymes

Compare fitness of predicted isozymes for: 2.6.1.-

Use Curated BLAST to search for 2.6.1.- or 2.6.1.87 or 2.6.1.92

Protein Sequence (384 amino acids)

>IAI46_11015 UDP-4-amino-4-deoxy-L-arabinose aminotransferase (Serratia liquefaciens MT49)
MDQFLPFSRPAIGDEEIAAVEKVLRSGWITTGPQNQQLESEFCATFGCKHAIAVCSATAG
MHITLMALGIGPGDEVITPSQTWVSTLNMIELLGATPVMIDVDRDTLMVNAKDVEAAITT
KTKAIVPVHYAGAPLPMDALRDVAKRHNLPLIEDAAHAVGSRYNGEWVGAQGTAIFSFHA
IKNLTCAEGGLIATDDDVLADRLRCLKFHGLAVDAFDRQQLGRKPQAEVVEPGYKYNLSD
IHAAIAVVQLARLPQLNARRKELAQRYLTALEGSPFLPLGLPDYPHDHAWHLFMVRVDAE
RCGIDRDQLMERLKEVGIGTGLHFRAAHTQKFYRDRYPQLSLPNTEWNSARLCTLPLFPD
MTDADVDRVVKALSSVVESLRVSR