Protein Info for IAI46_10850 in Serratia liquefaciens MT49

Annotation: hexitol phosphatase HxpB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00702: Hydrolase
  • amino acids 7 to 184 (178 residues), 86.4 bits, E=3.4e-28
• PF13419: HAD_2
  • amino acids 11 to 190 (180 residues), 84.9 bits, E=7.6e-28
• TIGR01509: HAD hydrolase, family IA, variant 3
  • amino acids 92 to 191 (100 residues), 40.9 bits, E=2.3e-14

Best Hits

Swiss-Prot: 64% identical to HXPB_ECOLI: Hexitol phosphatase B (hxpB) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 96% identity to spe:Spro_2125)

MetaCyc: 64% identical to hexitol phosphatase B (Escherichia coli K-12 substr. MG1655)
2-deoxyglucose-6-phosphatase. [EC: 3.1.3.68]; Sorbitol-6-phosphatase. [EC: 3.1.3.68, 3.1.3.50]; Mannitol-1-phosphatase. [EC: 3.1.3.68, 3.1.3.50, 3.1.3.22]

Predicted SEED Role

"2-deoxyglucose-6-phosphate hydrolase YniC" in subsystem 2-phosphoglycolate salvage

MetaCyc Pathways

• mannitol cycle (4/5 steps found)
• D-sorbitol biosynthesis I (2/3 steps found)
• mannitol biosynthesis (2/3 steps found)
• 2-deoxy-D-glucose 6-phosphate degradation (2/4 steps found)

KEGG Metabolic Maps

• Fructose and mannose metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.1.3.22 or 3.1.3.50 or 3.1.3.68

Protein Sequence (221 amino acids)

>IAI46_10850 hexitol phosphatase HxpB (Serratia liquefaciens MT49)
MAYSQRIETAIFDMDGLLIDSEPLWLQAELDIFGALGLDLSDRHKLPDTLGLRIDLVVKM
WYQAMPWQGVSQEEVSARIIERAIELVRETRPLLPGVQQALELCRSLDLNIGLASASPLH
MQQQVLQMFDLEGYFDQLVSAEYLPYSKPHPEVYLIAAERLGSDPLHCITLEDSFNGMIA
TKAARMRSIVIPAHEYRHDGRWALADHKLDSLEQLTSDHLA