Protein Info for IAI46_10600 in Serratia liquefaciens MT49

Annotation: beta-lactamase family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00144: Beta-lactamase
  • amino acids 22 to 322 (301 residues), 135.6 bits, E=1.2e-43

Best Hits

KEGG orthology group: None (inferred from 88% identity to spe:Spro_2075)

Predicted SEED Role

"D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4)" in subsystem Peptidoglycan Biosynthesis (EC 3.4.16.4)

MetaCyc Pathways

• peptidoglycan biosynthesis II (staphylococci) (12/17 steps found)
• peptidoglycan biosynthesis IV (Enterococcus faecium) (12/17 steps found)
• peptidoglycan maturation (meso-diaminopimelate containing) (4/12 steps found)

KEGG Metabolic Maps

• Peptidoglycan biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 3.4.16.4

Use Curated BLAST to search for 3.4.16.4

Protein Sequence (511 amino acids)

>IAI46_10600 beta-lactamase family protein (Serratia liquefaciens MT49)
MSEIPLNWRAAQAVANRLLADWQSDNQPGGAITLFDAAQVRATAYAGRADMAQNTPFNAD
TVVRYASVTKHIFATLALNATDQALSLNDRLGDLLPELRKPLANVTVGQALDMTSGLPDV
RETLGLLGISVHTRSEAQPVMQFLQGLEGLNYPAGSEITYTNTGYRLVEAALQAKGYDFD
QLVQQHLAQPLQVQLRAPESWYDVVPGLAPGYWRSEQGWQLACAGLHLSASGSLTGSANT
LTRWLQTLLANQGPGRGVLAQLSAPRHLNQGQVSAYGLGLAQTPLGEHRLLGHGGSHAGY
KTYFLLAPDRQAGVVVVANREDCDSFDMALQVMAALLGEALPKRSTAIPDGIYTTVADPY
WLEVKDGNVAYLGSEEALYQADDGYAVSLSAHMPMRLKWTGEAVEGEVCHVPRSFLPVTP
NRDCLKHVQGLWYHPQYRTAFEICGDRVHIGVGPSSQTGKISSLGQGRMLVESSDGPWLK
RFCLYFRGYSVDLIANRSRVLTFQRSSVDRD