Protein Info for IAI46_10580 in Serratia liquefaciens MT49

Annotation: nucleoside-specific channel-forming protein Tsx

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 291 signal peptide" amino acids 1 to 23 (23 residues), see Phobius details PF03502: Channel_Tsx" amino acids 31 to 291 (261 residues), 288.2 bits, see alignment E=3.1e-90

Best Hits

Swiss-Prot: 75% identical to TSX_KLEPN: Nucleoside-specific channel-forming protein Tsx (tsx) from Klebsiella pneumoniae

KEGG orthology group: K05517, nucleoside-specific channel-forming protein (inferred from 94% identity to spe:Spro_2072)

MetaCyc: 74% identical to nucleoside-specific channel-forming protein Tsx (Escherichia coli K-12 substr. MG1655)
TRANS-RXN0-468

Predicted SEED Role

"Nucleoside-specific channel-forming protein Tsx precursor"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (291 amino acids)

>IAI46_10580 nucleoside-specific channel-forming protein Tsx (Serratia liquefaciens MT49)
MKKIALAAGVLLAASYSASSMADSKDSQYVSDWWHQSVNVVGSYHTRFGPQLNNDLYLEY
EAFAKKDWFDFYGYIDVPKFFGVGNTPDRGIWDKGSPMFMEIEPRFSIDKLTGTDLSFGP
FKEWYFANNYIYDLGHNADGRQNTWYMGLGTDIDTGLPMSLSMNIYAKYQWENYQAANEN
SWDGYRFKVKYFVPLTQVWGGNLSYIGFTNFDFGSDLGKDDFTVNGRQARTSNSIASSHI
LALNYDHWHYSFVARYFHNGGQWQDGVDIGTPQGPIKSTGWGYYIVAGYNF