Protein Info for IAI46_10545 in Serratia liquefaciens MT49

Annotation: aldehyde dehydrogenase PuuC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00171: Aldedh
  • amino acids 32 to 492 (461 residues), 566.2 bits, E=4.6e-174

Best Hits

Swiss-Prot: 44% identical to AL1A2_MOUSE: Retinal dehydrogenase 2 (Aldh1a2) from Mus musculus

KEGG orthology group: K09472, gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase [EC: 1.2.1.-] (inferred from 95% identity to spe:Spro_2065)

MetaCyc: 60% identical to 4-guanidinobutyraldehyde dehydrogenase (Pseudomonas putida)
Gamma-guanidinobutyraldehyde dehydrogenase. [EC: 1.2.1.54]

Predicted SEED Role

"Gamma-glutamyl-aminobutyraldehyde dehydrogenase (EC 1.2.1.-)" (EC 1.2.1.-)

MetaCyc Pathways

• L-arginine degradation IX (arginine:pyruvate transaminase pathway) (2/4 steps found)
• L-arginine degradation VIII (arginine oxidase pathway) (2/4 steps found)

KEGG Metabolic Maps

• 1- and 2-Methylnaphthalene degradation
• Arginine and proline metabolism
• Geraniol degradation
• Limonene and pinene degradation
• Lysine biosynthesis
• Naphthalene and anthracene degradation
• Tryptophan metabolism
• Urea cycle and metabolism of amino groups

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.-

Use Curated BLAST to search for 1.2.1.- or 1.2.1.54

Protein Sequence (498 amino acids)

>IAI46_10545 aldehyde dehydrogenase PuuC (Serratia liquefaciens MT49)
MDFHHLQYWQHRAQALNIENRLFINGRYQQAAEGETFAVEDPAGQRELTQVARGSSVDID
LAVSAAREVFERGDWSRAAPSQRKATLLKLATLMEQHREELALLETLDTGKPIRHSLRDD
VPGAIRCLRWYAEAIDKVYGEIAPTGSDALALIEREPIGVVGAIVPWNFPLLLACWKLGP
ALATGNSVILKPSEKSPLSAIYLGQLAQQAGLPDGVLNIVPGYGHDAGKALALHNDVDAL
TFTGSTQVAKQLMIYAGQSNMKRVWLEAGGKSANIIFADCPDLDKAAQSAAAGIFYNQGQ
VCIAGTRLLVEESIQQEFLQALRRHAAAFAPGNPLDPATVMGTLIDQGHCEKVADYIEQG
LTQGAALFLDGREHPQGEHGGYLGPTILTQVDNAMSVARDEIFGPVLAVTSFSGEQQAMQ
LANDSDYGLGAAIWTRDLSRAHRLARQLKAGTVFVNNYNDGDMTVPFGGYKQSGNGRDKS
LHALDKFTELKTTWISLE