Protein Info for IAI46_10495 in Serratia liquefaciens MT49

Annotation: Gfo/Idh/MocA family oxidoreductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01408: GFO_IDH_MocA
  • amino acids 12 to 142 (131 residues), 85.4 bits, E=5.2e-28
• PF02894: GFO_IDH_MocA_C
  • amino acids 154 to 388 (235 residues), 103.4 bits, E=1.6e-33

Best Hits

Swiss-Prot: 58% identical to YFII_BACSU: Uncharacterized oxidoreductase YfiI (yfiI) from Bacillus subtilis (strain 168)

KEGG orthology group: None (inferred from 94% identity to spe:Spro_2055)

Predicted SEED Role

"Myo-inositol 2-dehydrogenase (EC 1.1.1.18)" in subsystem Inositol catabolism (EC 1.1.1.18)

MetaCyc Pathways

• myo-inositol degradation I (6/7 steps found)
• myo-, chiro- and scyllo-inositol degradation (6/10 steps found)
• myo-inositol degradation II (1/5 steps found)
• streptomycin biosynthesis (2/18 steps found)

KEGG Metabolic Maps

• Inositol phosphate metabolism
• Streptomycin biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.18

Use Curated BLAST to search for 1.1.1.18

Protein Sequence (390 amino acids)

>IAI46_10495 Gfo/Idh/MocA family oxidoreductase (Serratia liquefaciens MT49)
MINGIKPLERSLRWGMVGGGGTSQIGYIHRSAALRDGTFTLLAGAFDIDASRGRSFGQSL
GVAAERCYPDYATLFREEAARADGIEAVSIATPNNTHFAICQAALEAGLHVVCEKPLCFT
TQEAQALVELSQRQHKIIGVTYGYAGHQLILQARQMIADGQLGEIRIINMQFSHGFHAAP
VELDNPSTRWRVDPRFVGPSYVLGDLATHPLFLAETMVPQLKIKRLMCSRQSFVKTRAPL
EDNAYVLMEYDNGAVGSMWCSAVNSGSMHGQKVRIVGEKASLEWWDEQPNQLRFEVQGEP
VRILERGMSYLDPMALAEDRIGGGHSEGLFEAWSNLYRRFALAMDATDRRDEAFLAGFWY
PDVHAGAMGVRWVENCVRSADAGASWVAFR