Protein Info for IAI46_09975 in Serratia liquefaciens MT49

Annotation: prolyl oligopeptidase family serine peptidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 677 PF02897: Peptidase_S9_N" amino acids 5 to 404 (400 residues), 354.6 bits, see alignment E=6.9e-110 PF00326: Peptidase_S9" amino acids 462 to 674 (213 residues), 234.6 bits, see alignment E=9e-74

Best Hits

Swiss-Prot: 65% identical to PTRB_ECOLI: Protease 2 (ptrB) from Escherichia coli (strain K12)

KEGG orthology group: K01354, oligopeptidase B [EC: 3.4.21.83] (inferred from 97% identity to spe:Spro_1937)

MetaCyc: 65% identical to oligopeptidase B (Escherichia coli K-12 substr. MG1655)
Oligopeptidase B. [EC: 3.4.21.83]

Predicted SEED Role

"Protease II (EC 3.4.21.83)" (EC 3.4.21.83)

Isozymes

Compare fitness of predicted isozymes for: 3.4.21.83

Use Curated BLAST to search for 3.4.21.83

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (677 amino acids)

>IAI46_09975 prolyl oligopeptidase family serine peptidase (Serratia liquefaciens MT49)
MMTPPKAEKRPYPITVHGDTRVDDYYWLRDDDRADPQVLDYLQAENAFTDAALKPQQALR
ETLYEEMVARIPQQEHSVPYVRNGYRYQTRFEPGNEYAIYVRQPQAESEHWDTLIDGNQR
AEQREFYTLGGLEVSPDNQRLAVAEDFLSRRQYDIRFKNLSDDSWTDEVLENTSGNFEWA
NDSATVYYVRKHAKTLLPYQVYRHVVGTDPQLDELIYEELDDTFYVGLEKTTSERFILIH
LSSTTTSEILLLDADRADSTPQMFVPRRKDHEYGIDHYHQHFYIRSNKDGKNFGLYQSEQ
ADEAQWQTLIAPRVEVMLEGFSLFRDWLVVEERSEGLTQLRQIHWQSGEVKRIAFDDPTY
TTWLAYNPEPETELLRYGYSSMTTPTTLYELNLDSGERVMLKQQEVKNFTPENYRSERVW
VKARDGVEVPVSLVYRPDSFVHGSNPLMVYGYGSYGSSMDPAFSASRLSLLDRGFVFALA
HIRGGGELGQLWYEDGKLFNKQNTFNDFIDVTETLIAQGYGDAKRVFAMGGSAGGLLMGA
VINQAPQLFNGIVAQVPFVDVVTTMLDESIPLTTGEYDEWGNPNERAYYDYILQYSPYDQ
VKAQDYPHMLVTTGLHDSQVQYWEPAKWVAKLRELKTDDRQLLLYTDMDSGHGGKSGRFK
AYEDIALEYAFILALAE