Protein Info for IAI46_09270 in Serratia liquefaciens MT49

Annotation: glycine betaine/L-proline transporter ProP

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 transmembrane" amino acids 38 to 57 (20 residues), see Phobius details amino acids 65 to 87 (23 residues), see Phobius details amino acids 99 to 120 (22 residues), see Phobius details amino acids 123 to 123 (1 residues), see Phobius details amino acids 125 to 154 (30 residues), see Phobius details amino acids 168 to 189 (22 residues), see Phobius details amino acids 199 to 218 (20 residues), see Phobius details amino acids 261 to 279 (19 residues), see Phobius details amino acids 299 to 319 (21 residues), see Phobius details amino acids 328 to 347 (20 residues), see Phobius details amino acids 353 to 377 (25 residues), see Phobius details amino acids 389 to 412 (24 residues), see Phobius details amino acids 418 to 439 (22 residues), see Phobius details PF00083: Sugar_tr" amino acids 29 to 449 (421 residues), 244.6 bits, see alignment E=4.3e-76 TIGR00883: MFS transporter, metabolite:H+ symporter (MHS) family protein" amino acids 34 to 433 (400 residues), 470.9 bits, see alignment E=1.8e-145 PF07690: MFS_1" amino acids 60 to 306 (247 residues), 90.5 bits, see alignment E=2.2e-29 amino acids 274 to 440 (167 residues), 55.8 bits, see alignment E=7.7e-19 PF13347: MFS_2" amino acids 78 to 392 (315 residues), 40 bits, see alignment E=3.7e-14 PF08946: Osmo_CC" amino acids 455 to 500 (46 residues), 79.1 bits, see alignment 4.8e-26

Best Hits

Swiss-Prot: 79% identical to OUSA_DICD3: Glycine betaine/proline/ectoine/pipecolic acid transporter OusA (ousA) from Dickeya dadantii (strain 3937)

KEGG orthology group: None (inferred from 98% identity to srr:SerAS9_1803)

MetaCyc: 79% identical to osmolyte:H+ symporter ProP (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-29; TRANS-RXN-29A

Predicted SEED Role

"L-Proline/Glycine betaine transporter ProP" in subsystem Proline, 4-hydroxyproline uptake and utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (500 amino acids)

>IAI46_09270 glycine betaine/L-proline transporter ProP (Serratia liquefaciens MT49)
MKLRKKRHKPMHINDITIIDDSKLKKAITAAALGNAMEWFDFGVYGFVAYALGQVFFPGA
TPGVQMIAALATFSVPFLVRPLGGIFFGAMGDKFGRQKVLSITIIIMAVSTFCIGLIPSY
ASIGIWAPVLLLLAKLAQGFSVGGEYSGAAIFVAEYSPDRKRGFMGSWLDFGSIAGFVLG
AGVVVLISSIVGETNFLDWGWRIPFFIAAPLGLIGLYLRHALEETPAFQQHVEKMEKDDR
NAIENPPKTSFKEIAAKHWRSLLVCVGIVISTNVTYYMLLTYMPSYLSHNLHYSEDHGVL
IIIAIMIGMLFVQPVIGLASDRIGRKPFIIGGSVGLLALSIPCFILINSNVIGLIFVGLL
VLAVLLNSFTGVMASTLPAMFPTHIRYSALAISFNISVLVAGATPTVAAWLVEATGNLYM
PAYYLMVVAVIGLITGLYMKETANKPLRGATPAASDRSEAKELLQENYDNIEQKVEDINE
QIAELEKKKQTLIDQHPKLD