Protein Info for IAI46_09160 in Serratia liquefaciens MT49

Annotation: 4-hydroxyproline epimerase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF05544: Pro_racemase
  • amino acids 13 to 315 (303 residues), 323.2 bits, E=9e-101

Best Hits

Swiss-Prot: 70% identical to 4HYPE_PSEF5: 4-hydroxyproline 2-epimerase (PFL_1412) from Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)

KEGG orthology group: K12658, 4-hydroxyproline epimerase [EC: 5.1.1.8] (inferred from 94% identity to spe:Spro_1840)

MetaCyc: 66% identical to hydroxyproline 2-epimerase subunit (Pseudomonas putida)
4-hydroxyproline epimerase. [EC: 5.1.1.8]

Predicted SEED Role

"4-hydroxyproline epimerase (EC 5.1.1.8)" in subsystem Proline, 4-hydroxyproline uptake and utilization (EC 5.1.1.8)

MetaCyc Pathways

• trans-4-hydroxy-L-proline degradation II (4/4 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 5.1.1.8

Protein Sequence (315 amino acids)

>IAI46_09160 4-hydroxyproline epimerase (Serratia liquefaciens MT49)
MAHSSHFTALRAIDSHTAGEPTRLIIEGFPDLGSGSMAERKARFAQDYDDWRSAIILEPR
GNDVLVGALLCQPCSPQAAAGVIFFNNAGYLGMCGHGTIGLVASLAYLGRIGVGDHLIET
PVGTVNARLHEDGSVTVENVPAYRYRRQVRVEVSGYGPVVGDIAWGGNWFFLIGEHHLAI
DTQNLDALTAFCWAVRVALESAGIYGEDGGVIDHIELFAADPQVDSRNFVLCPGKAYDRS
PCGTGTSAKLACLAADGKLQPGVIWRQASVIGSQFSGYYQRNGDRVTPFIRGQAYVCADS
QLLLDERDPFVWGIR