Protein Info for IAI46_09150 in Serratia liquefaciens MT49

Annotation: dihydrodipicolinate synthase family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00701: DHDPS
  • amino acids 9 to 293 (285 residues), 200.7 bits, E=1.1e-63

Best Hits

Swiss-Prot: 31% identical to DAPA_PASMU: 4-hydroxy-tetrahydrodipicolinate synthase (dapA) from Pasteurella multocida (strain Pm70)

KEGG orthology group: K01714, dihydrodipicolinate synthase [EC: 4.2.1.52] (inferred from 98% identity to spe:Spro_1838)

Predicted SEED Role

"1-pyrroline-4-hydroxy-2-carboxylate deaminase (EC 3.5.4.22)" in subsystem Proline, 4-hydroxyproline uptake and utilization (EC 3.5.4.22)

MetaCyc Pathways

• trans-4-hydroxy-L-proline degradation II (4/4 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism
• Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
• Lysine biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 4.2.1.52

Use Curated BLAST to search for 3.5.4.22 or 4.2.1.52

Protein Sequence (306 amino acids)

>IAI46_09150 dihydrodipicolinate synthase family protein (Serratia liquefaciens MT49)
MSHKAISWSGVFPAVSTQFRSDFSLDLDATHTVIKNLVKDGVSGLVVCGTVGENTSLTVQ
EKLSVIEVARDAAQGQVPVIAGIAEFTTAFARNMAREAQKVGVDGIMVMPALVYSAKPHE
TATHFRSVATATDLPIMVYNNPPIYKNDVTPDILTSLVDCENIVCFKDSSGDTRRFIDLR
NEVGDRFVLFAGLDDVVLESIAVGAEGWISGMSNAFPREGETLFRLAKQKRFEEALALYS
WFMPLLHLDARPDLVQCIKLCEELVGRGSAITRPPRLALQGDTLAEVTAVVKKALANRPA
LPDVGL