Protein Info for IAI46_09135 in Serratia liquefaciens MT49
Annotation: Ldh family oxidoreductase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 66% identical to PY2CR_PSEAE: Delta(1)-pyrroline-2-carboxylate/Delta(1)-piperideine-2-carboxylate reductase (lhpD) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
KEGG orthology group: None (inferred from 92% identity to spe:Spro_1835)MetaCyc: 36% identical to R-sulfolactate oxidoreductase (Chromohalobacter salexigens DSM 3043)
RXN-11690 [EC: 1.1.1.338]
Predicted SEED Role
"Ureidoglycolate/malate/sulfolactate dehydrogenase family (EC 1.1.1.-)" in subsystem Proline, 4-hydroxyproline uptake and utilization (EC 1.1.1.-)
MetaCyc Pathways
- sulfolactate degradation I (1/3 steps found)
KEGG Metabolic Maps
- Alkaloid biosynthesis I
- Aminosugars metabolism
- Ascorbate and aldarate metabolism
- Benzoate degradation via CoA ligation
- Biosynthesis of alkaloids derived from shikimate pathway
- Biosynthesis of type II polyketide products
- Biosynthesis of unsaturated fatty acids
- Bisphenol A degradation
- Butanoate metabolism
- C21-Steroid hormone metabolism
- Fructose and mannose metabolism
- Glycine, serine and threonine metabolism
- Insect hormone biosynthesis
- Linoleic acid metabolism
- Nucleotide sugars metabolism
- Polyketide sugar unit biosynthesis
- Retinol metabolism
- Tetrachloroethene degradation
Isozymes
Compare fitness of predicted isozymes for: 1.1.1.-
Use Curated BLAST to search for 1.1.1.- or 1.1.1.338
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (337 amino acids)
>IAI46_09135 Ldh family oxidoreductase (Serratia liquefaciens MT49) MTQTQRLTLEQAYELALKALRSNGFSAEHADAVAQNVTAGERDGCASHGLYRVLGCVRSL LAGKVSADARPTLIDQAPAILRVDAHDAFSLLAYRTALPVFVEKVRTNGIAALAINHCVH YSALWADIEPLTDQGLVALACTPSHAWVTPAGGSRPLFGTNPIAFGWPRPQRPPFIFDMA TSAAARGEIELHRRAGTPLPPGWGIDQQGKPSTDAQSVLQGAMLTFGGHKGSALAAMVEL LAGPLIGDMTSKESLAYDRQTGSSPYGGELIIAMDPDRFLGPDKVAHLARAEALFADMSE QGARIPGERRFQQRQYSEQHGVTIPQALYEEIAALCR