Protein Info for IAI46_08550 in Serratia liquefaciens MT49

Annotation: thioredoxin-disulfide reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 323 signal peptide" amino acids 1 to 26 (26 residues), see Phobius details PF07992: Pyr_redox_2" amino acids 8 to 302 (295 residues), 174.5 bits, see alignment E=1e-54 TIGR01292: thioredoxin-disulfide reductase" amino acids 8 to 314 (307 residues), 408 bits, see alignment E=8.8e-127 PF13738: Pyr_redox_3" amino acids 55 to 286 (232 residues), 68.8 bits, see alignment E=1.5e-22 PF00070: Pyr_redox" amino acids 148 to 224 (77 residues), 54 bits, see alignment E=5.9e-18

Best Hits

Swiss-Prot: 85% identical to TRXB_ECOLI: Thioredoxin reductase (trxB) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 97% identity to srr:SerAS9_1661)

MetaCyc: 85% identical to thioredoxin reductase (Escherichia coli K-12 substr. MG1655)
Thioredoxin-disulfide reductase. [EC: 1.8.1.9]

Predicted SEED Role

"Thioredoxin reductase (EC 1.8.1.9)" in subsystem Glycine reductase, sarcosine reductase and betaine reductase or Thioredoxin-disulfide reductase or Wyeosine-MimG Biosynthesis (EC 1.8.1.9)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.8.1.9

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (323 amino acids)

>IAI46_08550 thioredoxin-disulfide reductase (Serratia liquefaciens MT49)
MGTAKHSKLLILGSGPAGYTAAVYAARANLSPVLITGMEQGGQLTTTTEVENWPGDAEDL
TGPALMERMREHAEKFQTEIVFDHITSVDLQNRPFRLFGDSGEYTCDALIIATGASARYL
GLPTEEAFKGKGVSACATCDGFFYRNQKVAVVGGGNTAVEEALYLSNIAAEVHLIHRRDS
FRSEKILINRLMEKVKNGNIVLHTDHTLDEVLGDEMGVTGVRIRSTKAENETRELALAGV
FIAIGHSPNTSIFGGQLELENGYIKVQSGIHGNATQTTIPGVFAAGDVMDHIYRQAITSA
GTGCMAALDAERYLDGIADAEVL