Protein Info for IAI46_08330 in Serratia liquefaciens MT49

Annotation: serine protease inhibitor ecotin

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 170 signal peptide" amino acids 1 to 22 (22 residues), see Phobius details PF03974: Ecotin" amino acids 38 to 160 (123 residues), 169.9 bits, see alignment E=1.1e-54

Best Hits

Swiss-Prot: 94% identical to ECOT_SERP5: Ecotin (eco) from Serratia proteamaculans (strain 568)

KEGG orthology group: K08276, ecotin (inferred from 94% identity to spe:Spro_1637)

Predicted SEED Role

"Proteinase inhibitor I11, ecotin precursor"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (170 amino acids)

>IAI46_08330 serine protease inhibitor ecotin (Serratia liquefaciens MT49)
MNKASVVFSGLLMAVSASAIAATSAEDTDISKQPLEKVAPYPKAEKGMSRQVIYLPKQEH
EENFKVELLIGKTLEVDCNYHMIGGTLESKTLSGWGYDYLVLEKLSDPASTLMGCPDNSK
QQKFIAANLGDASMQRYNSRLPIVVYVPKDVEVKYRVWKAEETVSKAEQK