Protein Info for IAI46_08140 in Serratia liquefaciens MT49

Annotation: UDP-galactopyranose mutase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 80% identical to GLF1_KLEPN: UDP-galactopyranose mutase (rfbD) from Klebsiella pneumoniae

KEGG orthology group: K01854, UDP-galactopyranose mutase [EC: 5.4.99.9] (inferred from 80% identity to rah:Rahaq_1755)

MetaCyc: 61% identical to dTDP-fucopyranose mutase (Escherichia coli O52)
RXN-14533 [EC: 5.4.99.59]

Predicted SEED Role

"UDP-galactopyranose mutase (EC 5.4.99.9)" in subsystem LOS core oligosaccharide biosynthesis or linker unit-arabinogalactan synthesis (EC 5.4.99.9)

MetaCyc Pathways

O-antigen building blocks biosynthesis (E. coli) (9/11 steps found)
superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis (5/6 steps found)
UDP-α-D-galactofuranose biosynthesis (2/2 steps found)
dTDP-β-D-fucofuranose biosynthesis (3/4 steps found)
superpathway of dTDP-glucose-derived O-antigen building blocks biosynthesis (5/19 steps found)
mycolyl-arabinogalactan-peptidoglycan complex biosynthesis (2/18 steps found)
superpathway of mycolyl-arabinogalactan-peptidoglycan complex biosynthesis (12/33 steps found)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 5.4.99.59 or 5.4.99.9

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (384 amino acids)

>IAI46_08140 UDP-galactopyranose mutase (Serratia liquefaciens MT49)
MNSKKILIVGAGFSGAVIGRQLAEQGHLIQIIDSRDHIAGNCYDARDVKTDVMVHTYGPH
IFHTDNEQVWNFVNRYSTMMPYVNRVKATVGGQVFSLPINLHTINQFFRQTCSPAEAKAL
IAEKGDRSITEPQSFEEQALRFVGKELYEAFFKGYTIKQWGMSPAQLPASILKRLPIRFN
YDDNYFNHKFQGMPKDGYTKMVEGILNHANITVSLGVQFQPQDREQYDHVFYSGPLDAFY
DFQFGRLGYRTLDFEKFSVEGDYQGCAVMNYCEQSVPYTRITEHKYFSPWEQHEGSVCYK
EYSRACEENDIPYYPIRQVGEMSLLEKYVDLAEKENGMTFIGRLGTYRYLDMDVTIAEAL
KTAEIYLSSLEQKTTMPVFTVSIR