Protein Info for IAI46_07720 in Serratia liquefaciens MT49

Annotation: choline dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 554 PF00732: GMC_oxred_N" amino acids 3 to 300 (298 residues), 198.8 bits, see alignment E=1.1e-62 TIGR01810: choline dehydrogenase" amino acids 4 to 537 (534 residues), 960.6 bits, see alignment E=1.1e-293 PF05199: GMC_oxred_C" amino acids 393 to 527 (135 residues), 141.8 bits, see alignment E=2.3e-45

Best Hits

Swiss-Prot: 97% identical to BETA_SERP5: Oxygen-dependent choline dehydrogenase (betA) from Serratia proteamaculans (strain 568)

KEGG orthology group: K00108, choline dehydrogenase [EC: 1.1.99.1] (inferred from 97% identity to spe:Spro_1515)

MetaCyc: 85% identical to choline dehydrogenase (Pseudomonas aeruginosa)
Choline dehydrogenase. [EC: 1.1.99.1]

Predicted SEED Role

"Choline dehydrogenase (EC 1.1.99.1)" in subsystem Choline and Betaine Uptake and Betaine Biosynthesis (EC 1.1.99.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.1.99.1

Use Curated BLAST to search for 1.1.99.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (554 amino acids)

>IAI46_07720 choline dehydrogenase (Serratia liquefaciens MT49)
MEYDYIIIGAGSAGNVLATRLTEDADVSVLLLEAGGPDYRMDFRTQMPAALAFPLQGRRY
NWAYETDPEPHMNNRRMECGRGKGLGGSSLINGMCYIRGNAMDFDNWAKAPGLEDWSYLD
CLPYFRKAETRDIGPNDYHGGDGPVSVTTPKAGNNELFHAMVEAGVQAGYPRTDDLNGYQ
QEGFGPMDRTVTPKGRRASTARGYLDQARSRSNLKIVTHALTDRIRFEGKRAVGVDYLQG
ESNQITSARARREVLLCAGAIASPQILQRSGVGPAALLNRLDIDLVHDLPGVGENLQDHL
EMYLQYACKKPVSLYPALQWFNQPKIGAEWLFNGTGVGASNQFEAGGFIRSREEFAWPNI
QYHFLPVAINYNGSNAVKEHGFQAHVGSMRSPSRGRVQVKSKDPRQHPSILFNYMATEQD
WQEFRDAIRITREIMAQPALDEYRGREISPGPEVQTDEQLDAFVREHAETAFHPSCSCKM
GEDEMAVVDGQGRVHGMEGLRVVDASIMPLIITGNLNATTIMIAEKIADRIRQRTPLPRS
NADYYVAGRRRPGA