Protein Info for IAI46_07590 in Serratia liquefaciens MT49

Annotation: HPr family phosphocarrier protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01261: AP_endonuc_2
  • amino acids 21 to 256 (236 residues), 175 bits, E=1.1e-55

Best Hits

Swiss-Prot: 66% identical to OTNI_PECAS: 2-oxo-tetronate isomerase (otnI) from Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672)

KEGG orthology group: K01816, hydroxypyruvate isomerase [EC: 5.3.1.22] (inferred from 88% identity to spe:Spro_1489)

MetaCyc: 61% identical to 2-dehydrotetronate isomerase (Haemophilus influenzae Rd KW20)
RXN-18592 [EC: 5.3.1.35]; 5.3.1.35 [EC: 5.3.1.35]

Predicted SEED Role

"Hydroxypyruvate isomerase (EC 5.3.1.22)" (EC 5.3.1.22)

MetaCyc Pathways

• L-threonate degradation (3/4 steps found)
• D-erythronate degradation II (2/4 steps found)

KEGG Metabolic Maps

• Glyoxylate and dicarboxylate metabolism

Isozymes

Compare fitness of predicted isozymes for: 5.3.1.22

Use Curated BLAST to search for 5.3.1.22 or 5.3.1.35

Protein Sequence (258 amino acids)

>IAI46_07590 HPr family phosphocarrier protein (Serratia liquefaciens MT49)
MPKFAANLSMMFNELPFLERFEAAAAEGFTAVEFLFPYDYPAELLTEQLRSNGLQQVLFN
TAPGNAEAGEWGLAAVPGREQDARADIDRALAYAIALNCPNVHVMAGVVPPGADWQRYRD
TFIDNIRYAADRFAQHDIKVLIEALSPQVKPHYLFSSQHQAAELVEAIDRSNVFVQFDFF
HAQLVDGNISGLMHSLAGRYAHIQIASVPDRHEPDDGELNYPWLFDQLDAIGYQGWIGCE
YRPRGDTTVGLDWLRPYQ