Protein Info for IAI46_06395 in Serratia liquefaciens MT49

Annotation: transporter substrate-binding domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1071 signal peptide" amino acids 1 to 22 (22 residues), see Phobius details transmembrane" amino acids 530 to 551 (22 residues), see Phobius details PF00497: SBP_bac_3" amino acids 58 to 267 (210 residues), 62.5 bits, see alignment E=1.1e-20 amino acids 301 to 509 (209 residues), 73 bits, see alignment E=6.6e-24 PF00512: HisKA" amino acids 576 to 637 (62 residues), 50.4 bits, see alignment 4.6e-17 PF02518: HATPase_c" amino acids 686 to 800 (115 residues), 101.4 bits, see alignment E=1e-32 PF00072: Response_reg" amino acids 824 to 938 (115 residues), 59.1 bits, see alignment E=1.1e-19 PF01627: Hpt" amino acids 972 to 1049 (78 residues), 36.2 bits, see alignment 1.5e-12

Best Hits

KEGG orthology group: K07679, two-component system, NarL family, sensor histidine kinase EvgS [EC: 2.7.13.3] (inferred from 89% identity to spe:Spro_1285)

Predicted SEED Role

"Virulence sensor protein bvgS precursor (EC 2.7.3.-)" (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3, 2.7.3.-

Use Curated BLAST to search for 2.7.13.3 or 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1071 amino acids)

>IAI46_06395 transporter substrate-binding domain-containing protein (Serratia liquefaciens MT49)
MMRALLLLVTMLLYVGSLAHAAQPVRYQLVSNLNIPPDLLIASEKNPWRDATLRIGIISE
NTSPYNIIVDDDLYGLNADYLGYVQQVTGIHFQIYGFSDLAKLEQALHDGTVDLVYGIPQ
NEALHGLKISQPYYVSNLRVLRDRSNDRKVMLNSANARVAISTLTDMQAGNALKTVSSHV
QRYDNNLQAVYALLNGSSDYFIADEASASFIIDQLQLGQLYQIESTLNLGNLSFVFAAAN
PALIETLNVAIADTPMELMNAIQSRWSKKIPSYLDTGNADLTQMEKSWVKTHPTVYYAAI
ENNFPFAYRGSGGQARGYAIDILNIIAQNTGLRFVPLWARNAEQADQLVQSGQASFRTAL
PLAREVKARYSASMPIHRSLWGVYVGQHDNGISTWSDLAGKRIGVLQGDLAQGLVPANEE
QIRFADSKAMYDALANGQLDALVDNVISANFVALSRYSGAIKLAFAANNIAYPVAFGVRQ
DQPLLLAILDKNLMQIPSETLQSLRDEWIVDRSNLIDAVNENRMQPQTTWLLALLAAAIL
LLLGLTLRRFILQRRDKREREVLEQARRHAEAENRMKSKFLATVSHELRTPMHAILGLLE
LELKRQPTPEGLPVIYSSASSLLNLLNDLQDHARLATGSLTLAPKAVALHPWVAHISALY
RPLIGERPVTLNVSAADNLPAAVLIDGERLLQVANNLINNAIKFTPRGSIQVSIGWREQS
AQQGELSLTVTDSGCGIAADEIGKLFQPFYRARGAQRVSVQGTGLGLSICKEIIEQMGGR
IELHSRLGVGTEVSLSVPVTEVALDSATQQTDKPLNLPPPSLRVALIDDHPTNLLLMERQ
LRHFGLQPTLFEQGYPLLKAHRRQPFDLLFIDYNMPRPDGLTLARLIRRDEQRHRRPACQ
IILCSADVQEFTRIPPELVAIDRFLTKPISLDALAQALPQQPQALEQQLVLTDLQQSLAD
MAGNDRPMIQRLATTLLTTLQQDRQRLALAAQSEDWLQLGQAAHRIKGSLLMLQLPAAAS
LCQQLVESGREGTLLQDAYTELSTLVEQILIELDDLVSANESYIAMHHKDE