Protein Info for IAI46_06295 in Serratia liquefaciens MT49

Annotation: cytochrome ubiquinol oxidase subunit I

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 522 transmembrane" amino acids 18 to 42 (25 residues), see Phobius details amino acids 54 to 73 (20 residues), see Phobius details amino acids 93 to 116 (24 residues), see Phobius details amino acids 128 to 150 (23 residues), see Phobius details amino acids 185 to 208 (24 residues), see Phobius details amino acids 220 to 238 (19 residues), see Phobius details amino acids 387 to 411 (25 residues), see Phobius details amino acids 424 to 444 (21 residues), see Phobius details amino acids 471 to 493 (23 residues), see Phobius details PF01654: Cyt_bd_oxida_I" amino acids 7 to 501 (495 residues), 565.2 bits, see alignment E=3.6e-174

Best Hits

Swiss-Prot: 88% identical to CYDA_SHIFL: Cytochrome bd-I ubiquinol oxidase subunit 1 (cydA) from Shigella flexneri

KEGG orthology group: K00425, cytochrome bd-I oxidase subunit I [EC: 1.10.3.-] (inferred from 98% identity to srs:SerAS12_1244)

MetaCyc: 88% identical to cytochrome bd-I subunit 1 (Escherichia coli K-12 substr. MG1655)
RXN0-5266 [EC: 7.1.1.7]; 1.11.1.- [EC: 7.1.1.7]; 1.11.1.- [EC: 7.1.1.7]

Predicted SEED Role

"Cytochrome d ubiquinol oxidase subunit I (EC 1.10.3.-)" in subsystem Terminal cytochrome d ubiquinol oxidases or Terminal cytochrome oxidases (EC 1.10.3.-)

MetaCyc Pathways

Isozymes

Compare fitness of predicted isozymes for: 1.10.3.-

Use Curated BLAST to search for 1.10.3.- or 7.1.1.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (522 amino acids)

>IAI46_06295 cytochrome ubiquinol oxidase subunit I (Serratia liquefaciens MT49)
MFDIVELSRLQFALTAMYHFLFVPLTLGMAFLLAIMETVYVLSGKQIYKDMTKFWGKLFA
INFALGVATGLTMEFQFGTNWSYFSHYVGDIFGAPLAIEGLMAFFLESTLVGLFFFGWDR
LGKVQHMAVTWLVALGSNFSALWILVANGWMQNPIASDFNFETMRMEMLSFSELVLNPVA
QVKFVHTVAAGYTCGAMFVLGISSYYLLKGRDTAFAKRSFAIAASFGMAAVLSVIVLGDE
SGYEMGDVQKTKLAAIEAEWDTQPAPASFTLFGIPNQDKMENSYAIQIPYALGLIATRST
DTQVTGLKDLMAQHEVRIRNGMKAYQLLEELRSGNTDPAVRAEFNKAKQDLGYGLLLKRY
TQNVTDATETQIQQATKDSIPRVAPLYFAFRIMVACGVLMLLIIGLSFWSVLRGRIGQRK
WLHRAALYGLPLPWIAIEAGWFVAEYGRQPWAIGEVLPTAVANSSLTAGDILFSMGLICG
LYTLFLVAEMYLMFKFARLGPSSLKTGRYHFEQPTAAVQEAR