Protein Info for IAI46_06270 in Serratia liquefaciens MT49

Annotation: succinate dehydrogenase iron-sulfur subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 238 PF13085: Fer2_3" amino acids 5 to 111 (107 residues), 107.7 bits, see alignment E=6e-35 TIGR00384: succinate dehydrogenase and fumarate reductase iron-sulfur protein" amino acids 7 to 230 (224 residues), 301.1 bits, see alignment E=2.1e-94 PF13183: Fer4_8" amino acids 146 to 220 (75 residues), 40.7 bits, see alignment E=5.8e-14 PF13534: Fer4_17" amino acids 148 to 221 (74 residues), 41.5 bits, see alignment E=3e-14 PF13237: Fer4_10" amino acids 148 to 217 (70 residues), 37.6 bits, see alignment E=3.6e-13

Best Hits

Swiss-Prot: 90% identical to SDHB_ECOLI: Succinate dehydrogenase iron-sulfur subunit (sdhB) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 96% identity to srr:SerAS9_1238)

MetaCyc: 90% identical to succinate:quinone oxidoreductase, iron-sulfur cluster binding protein (Escherichia coli K-12 substr. MG1655)

Predicted SEED Role

"Succinate dehydrogenase iron-sulfur protein (EC 1.3.99.1)" in subsystem Serine-glyoxylate cycle or Succinate dehydrogenase or TCA Cycle (EC 1.3.99.1)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.3.99.1

Use Curated BLAST to search for 1.3.99.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (238 amino acids)

>IAI46_06270 succinate dehydrogenase iron-sulfur subunit (Serratia liquefaciens MT49)
MKLEFSIYRYNPDVDDAPHMQDYSLEAEEGRDMMLLDALILLKEKDPSLSFRRSCREGVC
GSDGINMNGKNGLACITPISSLRKGNNKIVIRPLPGLPVVRDLVVDMGQFYTQYEKIKPY
LQNDGKNPPAREHLQSPEQRAKLDGLYECILCACCSTSCPSFWWNPDKFIGPAGLLAAYR
FLIDSRDTETEERLDDLDDAFSVFRCHSIMNCVSVCPKGLNPTRAIGHIKSMLLQRGA