Protein Info for IAI46_06220 in Serratia liquefaciens MT49

Annotation: biotin-dependent carboxyltransferase family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00724: biotin-dependent carboxylase uncharacterized domain
  • amino acids 1 to 309 (309 residues), 402.8 bits, E=4.4e-125
• PF02626: CT_A_B
  • amino acids 24 to 283 (260 residues), 326.7 bits, E=6.2e-102

Best Hits

Swiss-Prot: 67% identical to PXPC_ECOLI: 5-oxoprolinase subunit C (pxpC) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 91% identity to spe:Spro_1256)

MetaCyc: 67% identical to 5-oxoprolinase component C (Escherichia coli K-12 substr. MG1655)
5-oxoprolinase (ATP-hydrolyzing). [EC: 3.5.2.9]

Predicted SEED Role

"Allophanate hydrolase 2 subunit 2 (EC 3.5.1.54)" (EC 3.5.1.54)

MetaCyc Pathways

• 5-oxo-L-proline metabolism (6/6 steps found)
• uracil degradation III (5/5 steps found)
• L-citrulline degradation (3/3 steps found)
• cyanate degradation (3/3 steps found)
• urea degradation I (3/3 steps found)
• γ-glutamyl cycle (5/6 steps found)
• L-arginine degradation V (arginine deiminase pathway) (3/4 steps found)
• superpathway of allantoin degradation in yeast (4/6 steps found)
• cyanuric acid degradation I (3/5 steps found)
• cyanuric acid degradation II (3/5 steps found)
• allantoin degradation IV (anaerobic) (4/9 steps found)
• superpathway of atrazine degradation (3/8 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism
• Atrazine degradation
• Glutathione metabolism
• Urea cycle and metabolism of amino groups

Isozymes

Compare fitness of predicted isozymes for: 3.5.1.54

Use Curated BLAST to search for 3.5.1.54 or 3.5.2.9

Protein Sequence (310 amino acids)

>IAI46_06220 biotin-dependent carboxyltransferase family protein (Serratia liquefaciens MT49)
MLKILRAGIYTTVQDLGRNGFRRLGVSQGGALDEPALRIANLLVGNDTNAAGLEITLGQF
SAEFTRPGWIALTGAGCDAQLDGKPLWTGWRYQVSAGQQLMLKMPKRGMRSYLAIDGGIA
VPEILGSRSTDNKAAFGGLEGRNLRDGDCLPLGAGRELQKQSTGVKQLLFNNRIRALPGP
EYDEFSEEAKESFWRTAWQLSPQSNRMGYRLHGSSALNRTTEREMLSHGLLPGVVQVPHN
GQPIVLMADAQTTGGYPRIACVIEADLYHLAQIRLGEAIHFVPCTLAQAQRAKAEQEHFI
QQIAWGLDER