Protein Info for IAI46_05980 in Serratia liquefaciens MT49

Annotation: amino acid ABC transporter ATP-binding protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 241 PF00005: ABC_tran" amino acids 18 to 165 (148 residues), 123.5 bits, see alignment E=1.6e-39 PF03215: Rad17" amino acids 22 to 136 (115 residues), 25.6 bits, see alignment E=1.7e-09

Best Hits

Swiss-Prot: 90% identical to GLTL_ECO57: Glutamate/aspartate import ATP-binding protein GltL (gltL) from Escherichia coli O157:H7

KEGG orthology group: K10004, glutamate/aspartate transport system ATP-binding protein [EC: 3.6.3.-] (inferred from 99% identity to spe:Spro_1211)

MetaCyc: 90% identical to glutamate/aspartate ABC transporter ATP binding subunit (Escherichia coli K-12 substr. MG1655)
ABC-13-RXN [EC: 7.4.2.1]; 7.4.2.1 [EC: 7.4.2.1]

Predicted SEED Role

"Glutamate Aspartate transport ATP-binding protein GltL (TC 3.A.1.3.4)" (TC 3.A.1.3.4)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.-

Use Curated BLAST to search for 3.6.3.- or 7.4.2.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (241 amino acids)

>IAI46_05980 amino acid ABC transporter ATP-binding protein (Serratia liquefaciens MT49)
MISLKNVSKWYGHFQVLTDCTTEVKKGEVVVVCGPSGSGKSTLIKTVNGLEPIQQGNILV
NGTPVNDKKTNLAQLRSKVGMVFQHFELFPHLSIIDNLTLAQVKVLKRDKDASREKGLKL
LERVGLTAHANKFPGQLSGGQQQRVAIARALCMDPIAMLFDEPTSALDPEMINEVLDVMV
ELANEGMTMMVVTHEMGFARKVANRVIFMDEGKIVEDRNKDDFFNNPESERAKDFLAKIL
H