Protein Info for IAI46_05790 in Serratia liquefaciens MT49

Annotation: 2-hydroxymuconic semialdehyde dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR03216: 2-hydroxymuconic semialdehyde dehydrogenase
  • amino acids 11 to 488 (478 residues), 838.5 bits, E=7.2e-257
• PF00171: Aldedh
  • amino acids 21 to 484 (464 residues), 525.4 bits, E=5.7e-162

Best Hits

Swiss-Prot: 59% identical to DMPC_PSEUF: 2-hydroxymuconic semialdehyde dehydrogenase (dmpC) from Pseudomonas sp. (strain CF600)

KEGG orthology group: K10217, aminomuconate-semialdehyde dehydrogenase [EC: 1.2.1.32] (inferred from 72% identity to pol:Bpro_5132)

MetaCyc: 70% identical to 2-aminomuconate 6-semialdehyde dehydrogenase (Pseudomonas fluorescens KU-7)
Aminomuconate-semialdehyde dehydrogenase. [EC: 1.2.1.32]

Predicted SEED Role

"2-aminomuconate semialdehyde dehydrogenase (EC 1.2.1.32)" (EC 1.2.1.32)

MetaCyc Pathways

• 2-amino-3-carboxymuconate semialdehyde degradation to 2-hydroxypentadienoate (4/4 steps found)
• L-tryptophan degradation IX (9/12 steps found)
• L-tryptophan degradation XII (Geobacillus) (9/12 steps found)
• 2-aminophenol degradation (3/4 steps found)
• 2-nitrobenzoate degradation I (5/7 steps found)
• 2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA (3/5 steps found)
• L-tryptophan degradation III (eukaryotic) (8/15 steps found)
• 4-chloronitrobenzene degradation (3/9 steps found)
• 4-nitrotoluene degradation II (3/9 steps found)
• L-tryptophan degradation XI (mammalian, via kynurenine) (8/23 steps found)

KEGG Metabolic Maps

• Benzoate degradation via hydroxylation
• Toluene and xylene degradation
• Tryptophan metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.2.1.32

Protein Sequence (488 amino acids)

>IAI46_05790 2-hydroxymuconic semialdehyde dehydrogenase (Serratia liquefaciens MT49)
MYQSAPDLPLYIDGQFVDGIRQFDNISPVDGHLVSRVAEAGEAQVAAAVKAAHAALSGPW
GQLSVPERVALLHRVAEGIEARFDEFVAAEVADTGRPESLARTLDVPRAIANFRTFADLA
ATSVNECCETPQADGGLLFNYTVRKPLGVVAVISPWNLPLLLLTWKLGPALAMGNTVVCK
PSEETPSSATLLAHVMHEAGLPAGVFNLIHGFGPGSAGEYLTRQPEIAAVSFTGESRTGS
AIMKAVADGVKEISFELGGKNAAVVFADADFEAAVAGVTRSSFFNTGQVCLCSERVYVER
PIFDRFVAALKERAEALKIGYPDEEGVDLGPLVSQKHRDKVLSYFALARSEGATLITGGE
VPVFDDERDNGSWIRPTIWTGLGDDARCVREEIFGPVCHISPFDNEEEVLARVNDSQYGL
ACALWTSQVGRAHRLARRVHTGIVWVNSWYARDLRTPFGGSKLSGMGREGGRHSLDFYSE
ISNVCIKL