Protein Info for IAI46_05780 in Serratia liquefaciens MT49

Annotation: fumarylacetoacetate hydrolase family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01557: FAA_hydrolase
  • amino acids 73 to 247 (175 residues), 44.7 bits, E=6.8e-16

Best Hits

Swiss-Prot: 62% identical to AMNF_PSESP: 2-oxopent-4-enoate hydratase (amnF) from Pseudomonas sp.

KEGG orthology group: None (inferred from 66% identity to pol:Bpro_5134)

MetaCyc: 59% identical to 2-oxopent-4-enoate hydratase (Pseudomonas putida F1)
2-oxopent-4-enoate hydratase. [EC: 4.2.1.80]

Predicted SEED Role

"2-keto-4-pentenoate hydratase (EC 4.2.1.80)" (EC 4.2.1.80)

MetaCyc Pathways

• catechol degradation II (meta-cleavage pathway) (6/7 steps found)
• 2-hydroxypenta-2,4-dienoate degradation (3/3 steps found)
• catechol degradation I (meta-cleavage pathway) (4/5 steps found)
• L-tryptophan degradation IX (9/12 steps found)
• L-tryptophan degradation XII (Geobacillus) (9/12 steps found)
• toluene degradation I (aerobic) (via o-cresol) (4/7 steps found)
• toluene degradation V (aerobic) (via toluene-cis-diol) (4/7 steps found)
• meta cleavage pathway of aromatic compounds (6/10 steps found)
• toluene degradation II (aerobic) (via 4-methylcatechol) (2/6 steps found)
• 3-phenylpropanoate and 3-(3-hydroxyphenyl)propanoate degradation (3/8 steps found)
• p-cumate degradation (3/8 steps found)
• toluene degradation IV (aerobic) (via catechol) (6/13 steps found)
• 4-chloronitrobenzene degradation (3/9 steps found)
• naphthalene degradation to acetyl-CoA (5/12 steps found)
• p-cymene degradation (4/11 steps found)
• mandelate degradation to acetyl-CoA (7/18 steps found)
• superpathway of aerobic toluene degradation (14/30 steps found)
• superpathway of aromatic compound degradation via 3-oxoadipate (15/35 steps found)
• superpathway of aromatic compound degradation via 2-hydroxypentadienoate (14/42 steps found)

KEGG Metabolic Maps

• 1,4-Dichlorobenzene degradation
• Benzoate degradation via hydroxylation
• Biphenyl degradation
• Carbazole degradation
• Ethylbenzene degradation
• Fluorene degradation
• Phenylalanine metabolism
• Styrene degradation
• Toluene and xylene degradation

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.2.1.80

Protein Sequence (256 amino acids)

>IAI46_05780 fumarylacetoacetate hydrolase family protein (Serratia liquefaciens MT49)
MLRQAAESGRPCSPVRHLVGSQDIDAAYAVQRVNNQERIQKGHRPVGSKIGLTSAAVQRQ
LGVNQPDFGQLFADMALCDGEEIAAGRLIQPKVEAEIALVLERDLPHEKNTLADLIRATA
YLLPALEVVDSRIAGWDISLADTIADNASCGLFVLGNRPVLLKDVDLLGCGMVLERAGEP
VSVGAGAACLGNPLLAALWLADTLAQRGNALRAGDIILTGALGPMVAACAGDVFSARIEG
LGQVSGRFAPAAGGDQ