Protein Info for IAI46_05435 in Serratia liquefaciens MT49
Annotation: aldehyde dehydrogenase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 41% identical to ALDH_DEIRA: Aldehyde dehydrogenase (aldA) from Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
KEGG orthology group: None (inferred from 85% identity to spe:Spro_3867)MetaCyc: 39% identical to betaine aldehyde dehydrogenase subunit (Bacillus subtilis)
Betaine-aldehyde dehydrogenase. [EC: 1.2.1.8]
Predicted SEED Role
"Aldehyde dehydrogenase B (EC 1.2.1.22)" in subsystem Glycerolipid and Glycerophospholipid Metabolism in Bacteria or Methylglyoxal Metabolism (EC 1.2.1.22)
MetaCyc Pathways
- methylglyoxal degradation IV (3/3 steps found)
- methylglyoxal degradation V (3/3 steps found)
- L-lactaldehyde degradation (aerobic) (2/2 steps found)
- choline degradation I (2/2 steps found)
- glycine betaine biosynthesis I (Gram-negative bacteria) (2/2 steps found)
- glycine betaine biosynthesis II (Gram-positive bacteria) (2/2 steps found)
- superpathway of methylglyoxal degradation (6/8 steps found)
- choline-O-sulfate degradation (2/3 steps found)
- glycine betaine biosynthesis III (plants) (2/3 steps found)
- β-alanine biosynthesis I (1/2 steps found)
- β-alanine biosynthesis IV (1/2 steps found)
- choline degradation IV (2/4 steps found)
- dimethylsulfoniopropanoate biosynthesis I (Wollastonia) (1/3 steps found)
- lactate biosynthesis (archaea) (2/5 steps found)
- dimethylsulfoniopropanoate biosynthesis II (Spartina) (1/4 steps found)
- L-rhamnose degradation II (2/8 steps found)
- superpathway of fucose and rhamnose degradation (4/12 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 1.2.1.22, 1.2.1.8
Use Curated BLAST to search for 1.2.1.22 or 1.2.1.8
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (487 amino acids)
>IAI46_05435 aldehyde dehydrogenase (Serratia liquefaciens MT49) MTLDKAYGPLINGVFELDGTDIHPVISPSTGERLADLHYCNERDVERAVLAAEAAFPAWK ALGQQARARLVAQLADVLESDLERMAQIDARDVGRCISEVRRDYQTAVKHYRYFAAVVMG HEDSGRSIADGYSLAKREPLGVCGQIIPWNAPAIMAAFKLAPALVTGNTVVLKADENASF STLELGKMIANIFPAGVVNIITGLGSVAGAALTGNRKVRKLSFTGSTEVGKLVAKAAAER LVPVTLELGGKSPNIVFPDIEDLDAVVDNVTFAAIHNNGQSCLAGTRLFVHADIYDRFSA KLVTAFERVRVGSPLAEQSRVSCLVSEKQGERVLAYIRTGLEEGATLLTGGKRRAVAGCE HGYFIEPTIFAAENGMRICQEEIFGPVLTLIKWSDYDEMIAQANDSEYGLASGIYTRSLK NALATADRLEAGSVWINRYSNITDGTAFGGYKNSGIGREFCKETLNAYTQIKTITLQTDL PAAWFAE